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VOLUME 6 , ISSUE 3 ( September-December, 2012 ) > List of Articles

REVIEW ARTICLE

Imaging of the Lamina Cribrosa using Swept-Source Optical Coherence Tomography

Brenda Nuyen, Kaweh Mansouri, Robert N Weinreb

Keywords : Glaucoma, Intraocular pressure, Swept-source optical coherence tomography

Citation Information : Nuyen B, Mansouri K, Weinreb RN. Imaging of the Lamina Cribrosa using Swept-Source Optical Coherence Tomography. J Curr Glaucoma Pract 2012; 6 (3):113-119.

DOI: 10.5005/jp-journals-10008-1117

License: CC BY-NC 4.0

Published Online: 01-06-2019

Copyright Statement:  Copyright © 2012; The Author(s).


Abstract

The lamina cribrosa (LC) is the presumed site of axonal injury in glaucoma. Its deformation has been suggested to contribute to optic neuropathy by impeding axoplasmic flow within the optic nerve fibers, leading to apoptosis of retinal ganglion cells. To visualize the LC in vivo, optical coherence tomography (OCT) has been applied. Spectral domain (SD)-OCT, used in conjunction with recently introduced enhanced depth imaging (EDI)-OCT, has improved visualization of deeper ocular layers, but in many individuals it is still limited by inadequate resolution, poor image contrast and insufficient depth penetrance. The posterior laminar surface especially is not viewed clearly using these methods. New generation high-penetration (HP)-OCTs, also known as swept-source (SS)-OCT, are capable to evaluate the choroid in vivo to a remarkable level of detail. SS-OCTs use a longer wavelength (1,050 nm instead of 840 nm) compared to the conventional techniques. We review current knowledge of the LC, findings from trials that use SD-OCT and EDI-OCT, and our experience with a prototype SS-OCT to visualize the LC in its entirety.

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  1. Resnikoff S, et al. Global data on visual impairment in the year
  2. Bull World Health Organ 2004;82:844-51.
  3. Weinreb RN, Khaw PT. Primary open-angle glaucoma. Lancet 2004;363:1711-20.
  4. Quigley HA. Number of people with glaucoma worldwide. Br J Ophthalmol 1996;80:389-93.
  5. Javitt JC, Chiang YP. Preparing for managed competition. Utilization of ophthalmologic services varies by state. Arch Ophthalmol 1993;111:1469-70.
  6. Quigley HA, Vitale S. Models of open-angle glaucoma prevalence and incidence in the United States. Invest Ophthalmol Vis Sci 1997;38:83-91.
  7. Grytz R, Meschke G, Jonas JB. The collagen fibril architecture in the lamina cribrosa and peripapillary sclera predicted by a computational remodeling approach. Biomech Model Mechanobiol 2011;10:371-82.
  8. Fechtner RD, Weinreb RN. Mechanisms of optic nerve damage in primary open angle glaucoma. Surv Ophthalmol 1994;39:23-42.
  9. Mansouri K, Leite MT, Medeiros FA, Leung CK, Weinreb RN. Assessment of rates of structural change in glaucoma using imaging technologies. Eye (Lond) 2011;25:269-77.
  10. Varma R, Quigley HA, Pease ME. Changes in optic disk characteristics and number of nerve fibers in experimental glaucoma. Am J Ophthalmol 1992;114:554-59.
  11. Radius RL. Regional specificity in anatomy at the lamina cribrosa. Arch Ophthalmol 1981;99:478-80.
  12. Radius RL, Gonzales M. Anatomy of the lamina cribrosa in human eyes. Arch Ophthalmol 1981;99:2159-62.
  13. Tezel G, Trinkaus K, Wax MB. Alterations in the morphology of lamina cribrosa pores in glaucomatous eyes. Br J Ophthalmol 2004;88:251-56.
  14. Miller KM, Quigley HA. Comparison of optic disc features in low-tension and typical open-angle glaucoma. Ophthalmic Surg 1987;18:882-89.
  15. Fontana L, Bhandari A, Fitzke FW, Hitchings RA. In vivo morphometry of the lamina cribrosa and its relation to visual field loss in glaucoma. Curr Eye Res 1998;17:363-69.
  16. Morgan-Davies J, et al. Three-dimensional analysis of the lamina cribrosa in glaucoma. Br J Ophthalmol 2004;88:1299-1304.
  17. Quigley HA. Glaucoma. Lancet 2011;377:1367-77.
  18. Burgoyne CF. A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma. Exp Eye Res 2011;93:120-32.
  19. Downs JC, Roberts MD, Sigal IA. Glaucomatous cupping of the lamina cribrosa: A review of the evidence for active progressive remodeling as a mechanism. Exp Eye Res 2011;93:133-40.
  20. Kiumehr S, Park SC, Syril D, et al. In vivo evaluation of focal lamina cribrosa defects in glaucoma. Arch Ophthalmol 2012;130(5):552-59.
  21. Quigley HA, Hohman RM, Addicks EM, Massof RW, Green WR. Morphologic changes in the lamina cribrosa correlated with neural loss in open-angle glaucoma. Am J Ophthalmol 1983;95:673-91.
  22. Jonas JB, Berenshtein E, Holbach L. Lamina cribrosa thickness and spatial relationships between intraocular space and cerebrospinal fluid space in highly myopic eyes. Invest Ophthalmol Vis Sci 2004;45:2660-65.
  23. Downs JC, et al. Three-dimensional histomorphometry of the normal and early glaucomatous monkey optic nerve head: Neural canal and subarachnoid space architecture. Invest Ophthalmol Vis Sci 2007;48:3195-3208.
  24. Yang H, Downs JC, Bellezza A, Thompson H, Burgoyne CF. 3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: Prelaminar neural tissues and cupping. Invest Ophthalmol Vis Sci 2007;48:5068-84.
  25. Quigley HA, Addicks EM, Green WR, Maumenee AE. Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage. Arch Ophthalmol 1981;99:635-49.
  26. Quigley HA, Addicks EM. Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve damage. Arch Ophthalmol 1981;99:137-43.
  27. Park HY, Jeon SH, Park CK. Enhanced depth imaging detects lamina cribrosa thickness differences in normal tension glaucoma and primary open-angle glaucoma. Ophthalmology 2012; 119:10-20.
  28. Inoue R, et al. Three-dimensional high-speed optical coherence tomography imaging of lamina cribrosa in glaucoma. Ophthalmology 2009;116:214-22.
  29. Kagemann L, et al. Ultrahigh-resolution spectral domain optical coherence tomography imaging of the lamina cribrosa. Ophthalmic Surg Lasers Imaging 2008;39:S126-31.
  30. Strouthidis NG, et al. A comparison of optic nerve head morphology viewed by spectral domain optical coherence tomography and by serial histology. Invest Ophthalmol Vis Sci 2010;51:1464-74.
  31. Yeoh J, et al. Choroidal imaging in inherited retinal disease using the technique of enhanced depth imaging optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 2010; 248:1719-28.
  32. Dell'Omo, R, Costagliola C, Di Salvatore F, Cifariello F, Dell'Omo E. Enhanced depth imaging spectral-domain optical coherence tomography. Retina 2010;30:378-79.
  33. Zlotnik A, Ben-Yaish S, Zalevsky Z. Extending the depth of focus for enhanced three-dimensional imaging and profilometry: An overview. Appl Opt 2009;48:H105-12.
  34. Fujiwara T, Imamura Y, Margolis R, Slakter JS, Spaide RF. Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes. Am J Ophthalmol 2009;148: 445-50.
  35. Imamura Y, Fujiwara T, Margolis R, Spaide RF. Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy. Retina 2009;29:1469-73.
  36. Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol 2009;147:811-15.
  37. Spaide RF. Enhanced depth imaging optical coherence tomography of retinal pigment epithelial detachment in agerelated macular degeneration. Am J Ophthalmol 2009;147:644- 52.
  38. Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 2008;146:496-500.
  39. Jirarattanasopa P, et al. Assessment of macular choroidal thickness by optical coherence tomography and angiographic changes in central serous chorioretinopathy. Ophthalmology 2012;119(8):1666-78.
  40. Usui S, et al. Evaluation of the choroidal thickness using highpenetration optical coherence tomography with long wavelength in highly myopic normal-tension glaucoma. Am J Ophthalmol 2012;153:10-16, e11.
  41. Ikuno Y, Kawaguchi K, Nouchi T, Yasuno Y. Choroidal thickness in healthy Japanese subjects. Invest Ophthalmol Vis Sci 2010;51:2173-76.
  42. Park SC, et al. Enhanced depth imaging optical coherence tomography of deep optic nerve complex structures in glaucoma. Ophthalmology 2012;119:3-9.
  43. Goldenberg D, Moisseiev E, Goldstein M, Loewenstein A, Barak A. Enhanced depth imaging optical coherence tomography: Choroidal thickness and correlations with age, refractive error, and axial length. Ophthalmic Surg Lasers Imaging 2012;1-6.
  44. Rao RC, Choudhry N, Gragoudas ES. Enhanced depth imaging spectral-domain optical coherence tomography findings in sclerochoroidal calcification. Retina 2012;32:1226-27.
  45. Spaide RF, Akiba M, Ohno-Matsui K. Evaluation of peripapillary intrachoroidal cavitation with swept source and enhanced depth imaging optical coherence tomography. Retina 2012;32:1037-44.
  46. Chhablani J, et al. Repeatability and reproducibility of manual choroidal volume measurements using enhanced depth imaging optical coherence tomography. Invest Ophthalmol Vis Sci 2012;53:2274-80.
  47. Lee EJ, et al. Three-dimensional evaluation of the lamina cribrosa using spectral-domain optical coherence tomography in glaucoma. Invest Ophthalmol Vis Sci 2012;53:198-204.
  48. Unterhuber A, et al. In vivo retinal optical coherence tomography at 1040 nm - enhanced penetration into the choroid. Opt Express 2005;13:3252-58.
  49. Lee EC, de Boer JF, Mujat M, Lim H, Yun SH. In vivo optical frequency domain imaging of human retina and choroid. Opt Express 2006;14:4403-11.
  50. Yasuno Y, et al. In vivo high-contrast imaging of deep posterior eye by 1-microm swept-source optical coherence tomography and scattering optical coherence angiography. Opt Express 2007;15:6121-39.
  51. Huber R, Adler DC, Srinivasan VJ, Fujimoto JG. Fourier domain mode locking at 1050 nm for ultra-high-speed optical coherence tomography of the human retina at 236,000 axial scans per second. Opt Lett 2007;32:2049-51.
  52. Srinivasan VJ, et al. Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head. Invest Ophthalmol Vis Sci 2008;49:5103-10.
  53. de Bruin DM, et al. In vivo three-dimensional imaging of neovascular age-related macular degeneration using optical frequency domain imaging at 1050 nm. Invest Ophthalmol Vis Sci 2008;49:4545-52.
  54. Yasuno Y, et al. Visualization of subretinal pigment epithelium morphologies of exudative macular diseases by high-penetration optical coherence tomography. Invest Ophthalmol Vis Sci 2009;50:405-13.
  55. Chen Y, Burnes DL, de Bruin M, Mujat M, de Boer JF. Threedimensional pointwise comparison of human retinal optical property at 845 and 1060 nm using optical frequency domain imaging. J Biomed Opt 2009;14:024016.
  56. Agawa T, et al. Choroidal thickness measurement in healthy Japanese subjects by three-dimensional high-penetration optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 2011;249:1485-92.
  57. Ikuno Y, et al. Reproducibility of retinal and choroidal thickness measurements in enhanced depth imaging and high-penetration optical coherence tomography. Invest Ophthalmol Vis Sci 2011;52:5536-40.
  58. Hayreh SS. Blood supply of the optic nerve head. Ophthalmologica 1996;210:285-95.
  59. Hayreh SS. Blood flow in the optic nerve head and factors that may influence it. Prog Retin Eye Res 2001;20:595-624.
  60. Ernest JT. Optic disc blood flow. Trans Ophthalmol Soc UK 1976;96:348-51.
  61. Lieberman MF, Maumenee AE, Green WR. Histologic studies of the vasculature of the anterior optic nerve. Am J Ophthalmol 1976;82:405-23.
  62. Onda E, Cioffi GA, Bacon DR, Van Buskirk EM. Microvasculature of the human optic nerve. Am J Ophthalmol 1995;120:92-102.
  63. Olver JM, Spalton DJ, McCartney AC. Quantitative morphology of human retrolaminar optic nerve vasculature. Invest Ophthalmol Vis Sci 1994;35:3858-66.
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