Citation Information :
Costa L, Cunha JP, Amado D, Pinto LA, Ferreira J. Diabetes Mellitus as a Risk Factor in Glaucoma's Physiopathology and Surgical Survival Time: A Literature Review. J Curr Glaucoma Pract 2015; 9 (3):81-85.
Glaucoma is a multifactorial condition under serious influence of many risk factors. The role of diabetes mellitus (DM) in glaucoma etiology or progression remains inconclusive. Although, the diabetic patients have different healing mechanism comparing to the general population and it has a possible-negative role on surgical outcomes.
This review article attempts to analyze the association of both diseases, glaucoma and DM, before and after the surgery.
The epidemiological studies, based mainly in population prevalence analyzes, have shown opposite outcomes in time and even in the most recent articles also the association remains inconclusive. On the contrary, the experimental models based on animal induced chronic hyperglycemia have shown an important association of both diseases, explained by common neurodegenerative mechanisms.
Diabetic patients have a different wound healing process in the eye viz-a-viz other organs. The healing process is more and it results in lower surgical survival time, higher intraocular pressure (IOP) levels and, therefore, these patients usually need more medication to lower the IOP. Both randomized and nonrandomized retrospective and experimental molecular studies have shown the association between DM and glaucoma.
Further studies are needed to get better explanations about outcomes on more recent surgical procedures and with the exponential use of antifibrotics.
Weinreb R, Khaw PT. Primary open-angle glaucoma. Lancet 2004 May 22;363(9422):1711-1720.
Yip J, Sparrow J. Glaucoma clinical guidelines. Ophthalmol 2012 Feb;119(2):427-428.
Gupta N, Yücel YH. Glaucoma as neurodegenerative disease. Curr Opin Ophthalmol 2007 Mar;18(2):110-114.
Mitchell P, Surya F, Wong T, Chua B, Patel I, Ojaimi E. Clinical practice guidelines for the management of diabetic retinopathy. Nat Health and Med Res Council 2010.
Wong VH, Bui BV, Vingrys AJ. Clinical and experimental links between diabetes and glaucoma. Clin Exp Optom 2011 Jan;94(1):4-23.
Kanamori A, Nakamura M, Mukuno H, Maeda H, Negi A. Diabetes has an additive effect on neural apoptosis in rat retina with chronically elevated intraocular pressure. Curr Eye Res 2004 Jan;28(1):47-54.
Almasieh M, Wilson AM, Morquette B, Cueva Vargas JL, Di Polo A. The molecular basis of retinal ganglion cell death in glaucoma. Prog Retin Eye Res 2012 Mar;31(2):152-181.
Fletcher EL, Phipps JA, Wilkinson-Berka JL. Dysfunction of retinal neurons and glia during diabetes. Clin Exp Optom 2005 May;88(3):132-145.
Barber AJ. A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuropsychopharmacol Biol Psychiatry 2003 Apr;27(2):283-290.
Burgoyne CF, Downs JC, Bellezza AJ, Suh JK, Hart RT. The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage. Prog Retin Eye Res 2005 Jan;24(1):39-73.
Rudzinski M, Wong TP, Saragovi HU. Changes in retinal expression of neurotrophins and neurotrophin receptors induced by ocular hypertension. J Neurobiol 2004 Feb 15;58(3):341-354.
Kern TS, Barber AJ. Retinal ganglion cells in diabetes. J Physiol 2008 Sep 15;586(18):4401-4408.
Pease ME, McKinnon SJ, Quigley HA, Kerrigan-Baumrind LA, Zack DJ. Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. Invest Ophthalmol Vis Sci 2000 Mar;41(3):764-774.
Oshitari T, Fujimoto N, Hanawa K, Adachi-Usami E, Roy S. Effect of chronic hyperglycemia on intraocular pressure in patients with diabetes. Am J Ophthalmol 2007 Feb;143(2): 363-365. Epub 2006 Oct 17.
Ellis JD, Evans JM, Ruta DA, Baines PS, Leese G, MacDonald TM, Morris AD. Glaucoma incidence in an unselected cohort of diabetic patients: is diabetes mellitus a risk factor for glaucoma? Br J Ophthalmol 2000 Nov;84(11):1218-1224.
Armstrong JR, Daily RK, Dobson HL, Girard LJ. The incidence of glaucoma in diabetes mellitus. A comparison with the incidence of glaucoma in the general population. Am J Ophthalmol 1960 Jul;50:55-63.
Becker B. Diabetes mellitus and primary open-angle glaucoma. The XXVII Edward Jackson Memorial Lecture. Am J Ophthalmol 1971 Jan;71(1 Pt 1):1-16.
Klein B, Klein R, Moss SE. Intraocular pressure in diabetic persons. Ophthalmol 1984 Nov;91(11):1356-1360.
de Voogd S, Ikram MK, Wolfs RC, Jansonius NM, Witteman JC, Hofman A, de Jong P. Is diabetes mellitus a risk factor for open-angle glaucoma? The Rotterdam Study. Ophthalmol 2006;113:1827-1831.
Dielemans I, de Jong PT, Stolk R, Vingerling JR, Grobbee DE, Hofman A. Primary open-angle glaucoma, intraocular pressure, and diabetes mellitus in the general elderly population. The Rotterdam Study. Ophthalmol 1996 Aug;103(8):1271-1275.
Kahn HA, Leibowitz HM, Ganley JP, Kini MM, Colton T, Nickerson RS, Dawber TR. The Framingham Eye Study. II. Association of ophthalmic pathology with single variables previously measured in the Framingham Heart Study. Am J Epidemiol 1977 Jul;106(1):33-41.
Kahn HA, Milton RC. Alternative definitions of openangle glaucoma. Effect on prevalence and associations in the Framingham Heart Study. Arch Ophthalmol 1980 Dec;98(12):2172-2177.
Gordon MO, Beiser JA, Brandt JD, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, et al. The ocular hypertension treatment study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol 2002 Jun;120(6):714-720; discussion 829-830.
Tielsch JM, Katz J, Quigley HA, Javitt JC, Sommer A. Diabetes, intraocular pressure, and primary open-angle glaucoma in the Baltimore Eye Survey. Ophthalmol 1995 Jan;102(1):48-53.
Klein BE, Klein R, Jensen SC. Open-angle glaucoma and older-onset diabetes. The Beaver Dam Eye Study. Ophthalmol 1994 Jul;101(7):1173-1177.
Mitchell P, Smith W, CHey T, Healey PR. Open-angle glaucoma and diabetes: the Blue Mountains eye study, Australia. Ophthalmol 1997 Apr;104(4):712-718.
Coleman AL, Miglior S. Risk factors for glaucoma onset and progression. Surv Ophthalmol 2008 Nov;53 Suppl 1: S3-10. doi: 10.1016/j.survophthal.2008.08.006.
Melville N. Metformin inked to reduced risk for glaucoma. Annual Meeting of ARVO 2014 (Online).
Law SK, Hosseini H, Saidi E, Nassiri N, Neelakanta G, Giaconi JA, Caprioli J. Long-term outcomes of primary trabeculectomy in diabetic patients with primary open-angle glaucoma. Br J Ophthalmol 2013 May;97(5):561-566.
The AGIS investigators. The advanced glaucoma intervention study (AGIS): 11. Risk factors for failure of trabeculectomy and argon laser trabeculoplasty. Am J Ophthalmol 2002 Oct;134(4):481-498.
Broadway DC, Chang LP. Trabeculectomy, risk factors for failure and preoperative state of the conjunctiva. J Glaucoma 2001 Jun;10(3):237-249.
Edmunds B, Bunce CV, Thompson JR, Salmon JF, Wormald RP. Factors associated with success in first-time trabeculectomy for patients at low risk of failure with chronic open-angle glaucoma. Ophthalmol 2004 Jan;111(1):97-103.
Mariotii C, Dahan E, Nicolai M, Levitz L, Bouee S. Long-term outcomes and risk factors for failure with Ex-press glaucoma drainage device. Eye(Lond) 2014 Jan;28(1):1-8.
Huddleston SM, Feldman RM, Budenz DL, Bell NP, Lee DA, Chuang AZ, Mankiewicz KA, Koval MS, Truong E, Moraczewski A. Aqueous shunt exposure: a retrospective review of repair outcome. J Glaucoma 2013 Aug;22(6):433-438.
Byon Y, Lee N, Park C. Risk factors of implant exposure outside the conjunctiva after Ahmed glaucoma valve implantation. Jpn J Ophthalmol 2009 Mar;53(2):114-119.
Browning AC, Alibhai A, Mcintosh RS, Rotchord AP, Bhan A, Amoaku WM. Effect of diabetes mellitus and hyperglycemia on the proliferation of human Tenon's capsule fibroblasts: implications for wound healing after glaucoma drainage surgery. Wound Repair Regen 2005 May-Jun;13(3):295-302.
Kottler UB, Junemann AG, Aigner T, Zenkel M, Rummelt C, Schlötzer-Schrehardt U. Comparative effects of TGF-beta 1 and TGF-beta 2 on extracellular matrix production, proliferation, migration, and collagen contraction of human Tenon's capsule fibroblasts in pseudoexfoliation and primary open-angle glaucoma. Exp Eye Res 2005 Jan;80(1):121-134.
Denk PO, Hoppe J, Hoppe V, Knorr M. Effect of growth factors on the activation of human Tenon's capsule fibroblasts. Curr Eye Res 2003 Jul;27(1):35-44.