Journal of Current Glaucoma Practice

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VOLUME 8 , ISSUE 3 ( September-December, 2014 ) > List of Articles

Original Article

Screening First Degree Relatives of Persons with Primary Open Angle Glaucoma in India

Sharmila Rajendrababu, B Vijayakumar, R Kumaragurupari, SR Krishnadas

Keywords : Primary open angle glaucoma, Family glaucoma, Family history, Heredity history, Heredity, Risk factor, Targeted factor, Targeted screening, First degree relatives

Citation Information : Rajendrababu S, Vijayakumar B, Kumaragurupari R, Krishnadas S. Screening First Degree Relatives of Persons with Primary Open Angle Glaucoma in India. J Curr Glaucoma Pract 2014; 8 (3):107-112.

DOI: 10.5005/jp-journals-10008-1172

License: CC BY-NC 4.0

Published Online: 01-06-2019

Copyright Statement:  Copyright © 2014; The Author(s).


Purpose: To report the results of screening first degree relatives of persons identified with primary open angle glaucoma in a tertiary eye hospital glaucoma services. Design: A cross-sectional study of first degree relatives of persons with primary open angle glaucoma. Materials and methods: First degree relatives of patients identified with primary open angle glaucoma were invited to participate in a screening evaluation in the base hospital to detect glaucoma. All participating individuals had comprehensive eye examination including vision screening, refraction, slit-lamp biomicroscopy, applanation tonometry, gonioscopy, frequency doubling peri-metry and dilated fundus examination. Persons with definite and suspected glaucoma were subject to full threshold automated perimetry. Results: A 514 first degree relatives of 346 persons with primary open angle glaucoma, of 4972 individuals who were invited to participate attended the screening examination (Response Rate 7%). Fifty-five percent of those who attended were males and mean age of participants was 56.8 years. Sixty-eight relatives (13.3% of those screened) were detected to have definite glaucoma. Sixty percent of those detected with definite glaucoma were siblings. Fifteen percent of siblings, 4% of off-springs and 20% of parents who attended the screening examination had definite open angle glaucoma. Conclusion: Prevalence of open angle glaucoma amongst first degree relatives of persons with glaucoma is higher than in the general population as reported in previous studies. Significant barriers, however, exist in the uptake of eye care services among relatives of persons known to have primary open angle glaucoma.

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  1. Resnikoff S, Pascolini D, Etya'ale D, Kocur I, Pararajasegaram R, Pokharel GP, Mariotti SP. Global data on visual impairment in the year 2002. Bull World Health Organ 2004 Nov;82(11):844-851.
  2. Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol 2006 Mar;90(3):262-267.
  3. George R, Ve RS, Vijaya L. Glaucoma in India: estimated burden of disease. J Glaucoma 2010 Aug;19(6):391-397.
  4. Ramakrishnan R, Nirmalan PK, Krishnadas R, Thulasiraj RD, Tielsch JM, Katz J, Friedman DS, Robin AL. Glaucoma in a rural population of southern India: the Aravind comprehensive eye survey. Ophthalmology 2003 Aug;110(8):1484-1490.
  5. Hernández RA, Burr JM, Vale LD, OAG Screening project group. Economic evaluation of screening for open-angle glaucoma. Int J Technol Assess Health Care 2008;24(2):203-211.
  6. De Voogd S, Ikram MK, Wolfs RC, Jansonius NM, Hofman A, de Jong PT. Incidence of open-angle glaucoma in a general elderly population: the Rotterdam Study. Ophthalmology 2005 Sep;112(9):1487-1493.
  7. Friedman DS, Wolfs RC, O'Colmain BJ, Klein BE, Taylor HR, West S, Leske MC, Mitchell P, Congdon N, Kempen J. Prevalence of open-angle glaucoma among adults in the United States. Arch Ophthalmol 2004 Apr;122(4): 532-538.
  8. Tielsch JM, Sommer A, Katz J, Royall RM, Quigley HA, Javitt J. Racial variations in the prevalence of primary openangle glaucoma. The Baltimore Eye Survey. JAMA 1991 Jul;266(3):369-374.
  9. Quigley HA, West SK, Rodriguez J, Munoz B, Klein R, Snyder R. The prevalence of glaucoma in a population-based study of Hispanic subjects: Proyecto VER. Arch Ophthalmol 2001 Dec;119(12):1819-1826.
  10. Varma R, Ying-Lai M, Francis BA, Nguyen BB-T, Deneen J, Wilson MR, Azen SP. Prevalence of open-angle glaucoma and ocular hypertension in Latinos: the Los Angeles Latino Eye Study. Ophthalmology 2004 Aug;111(8):1439-1448.
  11. Wolfs RC, Klaver CC, Ramrattan RS, van Duijn CM, Hofman A, de Jong PT. Genetic risk of primary open-angle glaucoma. Population-based familial aggregation study. Arch Ophthalmol 1998 Dec;116(12):1640-1645.
  12. Tielsch JM, Katz J, Sommer A, Quigley HA, Javitt JC. Family history and risk of primary open angle glaucoma. The Baltimore Eye Survey. Arch Ophthalmol 1994 Jan;112(1):69-73.
  13. Leske MC, Connell AM, Wu SY, Nemesure B, Li X, Schachat A, Hennis A. Incidence of open-angle glaucoma: the Barbados Eye Studies. The Barbados Eye Studies Group. Arch Ophthalmol 2001 Jan;119(1):89-95.
  14. Nguyen RL, Raja SC, Traboulsi EI. Screening relatives of patients with familial chronic open angle glaucoma. Ophthalmology 2000 Jul;107(7):1294-1297.
  15. Leske MC, Wu SY, Hennis A, Honkanen R, Nemesure B, BESs study group. Risk factors for incident open-angle glaucoma: the Barbados Eye Studies. Ophthalmology 2008 Jan;115(1):85-93.
  16. Okeke CN, Friedman DS, Jampel HD, Congdon NG, Levin L, Lai H, Quigley HA. Targeting relatives of patients with primary open angle glaucoma: the help the family glaucoma project. J Glaucoma 2007 Sep;16(6):549-555.
  17. Sung VC, Koppens JM, Vernon SA, Pawson P, Rubinstein M, King AJ, Tattersall CL. Longitudinal glaucoma screening for siblings of patients with primary open angle glaucoma: the Nottingham Family Glaucoma Screening Study. Br J Ophthalmol 2006 Jan;90(1):59-63.
  18. Nemesure B, Leske MC, He Q, Mendell N. Analyses of reported family history of glaucoma: a preliminary investigation. The Barbados Eye Study Group. Ophthalmic Epidemiol 1996 Dec;3(3):135-141.
  19. Leighton DA. Survey of the first-degree relatives of glaucoma patients. Trans Ophthalmol Soc UK 1976 Apr;96(1):28-32.
  20. Posner A, Schlossman A. Role of inheritance in glaucoma. Arch Ophthal 1949 Feb;41(2):125-150.
  21. François J. Genetics and primary open-angle glaucoma. Am J Ophthalmol 1966 Apr;61(4):652-665.
  22. Becker B, Kolker AE, Roth FD. Glaucoma family study. Am J Ophthalmol 1960 Oct;50(4):557-567.
  23. Kellerman L, Posner A. The value of heredity in the detection and study of glaucoma. Am J Ophthalmol 1955 Nov;40(5 Part 1): 681-685.
  24. Shin DH, Becker B, Kolker AE. Family history in primary openangle glaucoma. Arch Ophthalmol 1977 Apr;95(4):598-600.
  25. Rosenthal AR, Perkins ES. Family studies in glaucoma. Br J Ophthalmol 1985 Sep;69(9):664-667.
  26. Miller SJ, Paterson GD. Studies on glaucoma relatives. Br J Ophthalmol 1962 Sep;46(9):513-552.
  27. Wilson MR, Hertzmark E, Walker AM, Childs-Shaw K, Epstein DL. A case-control study of risk factors in open angle glaucoma. Arch Ophthalmol 1987 Aug;105(8):1066-1071.
  28. Tielsch JM, Katz J, Singh K, Quigley HA, Gottsch JD, Javitt J, Sommer A. A population-based evaluation of glaucoma screening: the Baltimore Eye Survey. Am J Epidemiol 1991 Nov15;134(10):1102-1110.
  29. Vegini F, Figueiroa Filho N, Lenci RF, Garcia Neto D, Susanna Junior R. Prevalence of open angle glaucoma in accompanying first degree relatives of patients with glaucoma. Clinics (Sao Paulo) 2008 Jun;63(3):329-332.
  30. Krishnaiah S, Kovai V, Srinivas M, Shamanna BR, Rao GN, Thomas R. Awareness of glaucoma in the rural population of Southern India. Indian J Ophthalmol 2005 Sep;53(3):205-208.
  31. Leske MC, Connell AM, Wu SY, Hyman LG, Schachat AP. Risk factors for open-angle glaucoma. The Barbados Eye Study. Arch Ophthalmol 1995 Jul;113(7):918-924.
  32. Nemesure B, He Q, Mendell N, Wu SY, Hejtmancik JF, Hennis A, Leske MC. Inheritance of open-angle glaucoma in the Barbados family study. Am J Med Genet 2001 Sep 15;103(1):36-43.
  33. Bengtsson BO. Incidence of manifest glaucoma. Br J Ophthalmol 1989 Jul;73(7):483-487.
  34. Mukesh BN, McCarty CA, Rait JL, Taylor HR. Five -year incidence of open-angle glaucoma: the visual impairment project. Ophthalmology 2002 Jun;109(6):1047-1051.
  35. Quigley HA. Chase the family. Arch Ophthalmol 2006 Jul;124(7):1036-1037.
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