Aim: To compare the difference of retinal macular thickness and macular volume using optical coherence tomography (OCT) in primary open angle glaucoma (POAG) patients with the normal subjects.
Materials and methods: This observational case control study included primary open angle glaucoma (POAG) patients (n = 124 eyes) and healthy subjects in the control group (n = 124 eyes). All subjects underwent detailed history, general and systemic exami -nation. Complete ocular examination included best corrected visual acuity (BCVA), slit lamp examination, intraocular pressure (IOP), central corneal thickness, gonioscopy, dilated fundus biomicroscopy. Field analysis was done by white on white Humphrey Field Analyzer (Carl Zeiss).
Optical coherence tomography imaging of macular area was performed using Stratus OCT (OCT 3, Version 4, Carl Zeiss Inc, Dublin, California, USA). In both these groups, parameters analyzed were macular thickness, inner macular thicknesses (IMT), outer macular thicknesses (OMT), central macular thick ness (CMT) and total macular volume (TMV).
Results: The POAG group had significantly decreased values of TMV, OMT and IMT, compared to control group, while there was no difference in CMT, presumably due to absence of ganglion cells in the central part. Thus, macular thickness and volume parameters may be used for making the diagnosis of glaucoma especially in patients with abnormalities of disc.
Conclusion: Macular thickness parameters correlated well with the diagnosis of glaucoma.
Quigley HA, Dunkelberger GR, Green WR. Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma. Am J Ophthalmol 1989 May 15;107(5):453-464.
Harwerth RS, Quigley HA. Visual field defects and retinal ganglion cell losses in patients with glaucoma. Arch Ophthalmol 2006 Jun;124(6):853-859.
Harwerth RS, Carter-Dawson L, Shen F, Smith EL 3rd, Crawford ML. Ganglion cell losses underlying visual field defects from experimental glaucoma. Invest Ophthalmol Vis Sci 1999 Sep;40(10): 2242-2250.
Curcio CA, Allen KA. Topography of ganglion cells in human retina. J Comp Neurol 1990 Oct 1;300:5-25.
Wässle H, Grünert U, Röhrenbeck J, Boycott BB. Cortical magnification factor and ganglion cell density in primate retina. Nature 1989 Oct;341(6243):643-646.
Garway-Heath DF, Caprioli J, Fitzke FW, Hitchings RA. Scaling the hill of vision: the physiological relationship between light sensitivity and ganglion cell numbers. Invest ophthalmol Vis Sci 2000 Jun;41(7):1774-1782.
Zeimer R, Asrani S, Zou S, Quigley H, Jampel H. Quantitative detection of glaucomatous damage at the posterior pole by retinal thickness mapping. A pilot study. Ophthalmology 1998 Feb;105(2):224-231.
Guedes V1, Schuman JS, Hertzmark E, Wollstein G, Correnti A, Mancini R, Lederer D, Voskanian S, Velazquez L, Pakter HM, et al. Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes. Ophthalmology 2003 Jan;110(1):177-189.
Wollstein G, Schuman JS, Price LL, Aydin A, Beaton SA, Stark PC, Fujimoto JG, Ishikawa H. Optical coherence tomography (OCT) macular and peripapillary retinal nerve fiber layer measurements and automated visual fields. Am J Ophthalmol 2004Aug;138(2):218-225.
Rao HL, Zangwill LM, Weinreb RN, Sample PA, Alencar LM, Medeiros FA. Comparison of different spectral domain optical coherence tomography scanning areas for glaucoma diagnosis. Ophthalmology 2010 Sep;117(9):1692-1699.
Tan O, Chopra V, Lu AT, Schuman JS, Ishikawa H, Wollstein G, Varma R, Huang D. Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography. Ophthalmology 2009 Dec;116(12):2305-2314.e1-e2.
Hodapp, E.; Parrish, RK II.; Anderson, DR. Clinical decisions in glaucoma. 1st ed. St Louis: Mosby Year Book; 1993 Jan. p. 56-59.
Kanadani FN, Hood DC, Grippo TM, Wangsupadilok B, Harizman N, Greenstein VC, Liebmann JM, Ritch R. Structural and functional assessment of macular region in patients with glaucoma. Br J Ophthalmol 2006 Nov;90(11):1393-1397.
Sung MS, Yoon JH, Park SW. Diagnostic validity of macular ganglion cell-inner plexiform layer thickness deviation map algorithm using cirrus HD-OCT in preperimetric and early glaucoma. J Glaucoma 2014 Oct-Nov;23(8).e144-e151.
Delbarre M, El Chehab H, Francoz M, Zerrouk R, Marechal M, Marill AF, Giraud JM, Maÿ F, Renard JP. Diagnostic use of macular layer analysis by SD-OCT in primary open angle glaucoma. J Fr Ophthalmol 2013 Nov;36(9):723-731.
Arvanitaki V, Tsilimbaris MK, Pallikaris A, Moschandreas I, Minos E, Pallikaris IG, Detorakis ET. Macular retinal and nerve fiber layer thickness in early glaucoma: clinical correlations. Middle East Afr J Ophthalmol 2012 Apr-Jun;19(2):204-210.
Medeiros FA, Zangwill LM, Bowd C, Vessani RM, Susanna R Jr, Weinreb RN. Evaluation of retinal nerve fiber layer, optic nerve head and macular thickness measurements for glaucoma detection using optical coherence tomography. Am J Ophthalmol 2005 Jan;139(1):44-55.
Muscat S, Parks S, Kemp E, Keating D. Repeatability and reproducibility of macular thickness measurements with the Humphrey OCT system. Invest Ophthalmol Vis Sci 2002 Feb;43(2):490-495.
Koozekanani D, Roberts C, Katz SE, Herderick EE. Intersession repeatability of macular thickness measurements with the Humphrey 2000 OCT. Invest Ophthalmol Vis Sci 2000 May;41(6):1486-1491.
Giovannini A, Amato G, Mariotti C. The macular thickness and volume in glaucoma: an analysis in normal and glaucomatous eyes using OCT. Acta Ophthalmol Scand Suppl 2002;236:34-36.
Lederer DE, Schuman JS, Hertzmark E, Heltzer J, Velazques LJ, Fujimoto JG, Mattox C. Analysis of macular volume in normal and glaucomatous eyes using optical coherence tomography. Am J Ophthalmol 2003 Jan;135(6):838-843.
