Journal of Current Glaucoma Practice

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VOLUME 6 , ISSUE 2 ( May-August, 2012 ) > List of Articles


Anterior Segment Optical Coherence Tomography and its Clinical Applications in Glaucoma

Haitao Li, Vishal Jhanji, Syril Dorairaj, Andrea Liu, Dennis SC Lam, Christopher K Leung

Keywords : Optical coherence tomography, Anterior segment, Anterior chamber angle

Citation Information : Li H, Jhanji V, Dorairaj S, Liu A, SC Lam D, K Leung C. Anterior Segment Optical Coherence Tomography and its Clinical Applications in Glaucoma. J Curr Glaucoma Pract 2012; 6 (2):68-74.

DOI: 10.5005/jp-journals-10008-1109

License: CC BY-NC 4.0

Published Online: 01-09-2018

Copyright Statement:  Copyright © 2012; The Author(s).


Anterior segment optical coherence tomography (ASOCT) is an imaging modality that provides both quantitative and qualitative information on the cornea, anterior chamber angle, iris and crystalline lens. ASOCT shows excellent repeatability and reproducibility for the measurement of corneal thickness, anterior chamber angle and anterior chamber depth. With realtime video recording, ASOCT can also effectively capture the dynamic changes of the iris and lens in response to light and eye accommodation. With this additional information, physiological and pathological changes of the anterior segment structures are now better understood. This article aims to provide an overview of the current applications of ASOCT in glaucoma.

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  1. Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA, et al. Optical coherence tomography. Science 1991 Nov;254(5035):1178- 1181.
  2. Bechmann M, Thiel MJ, Neubauer AS, Ullrich S, Ludwig K, Kenyon KR, Ulbig MW. Central corneal thickness measurement with a retinal optical coherence tomography device versus standard ultrasonic pachymetry. Cornea 2001 Jan;20(1):50-54.
  3. Leung CK, Chan WM, Ko CY, Chui SI, Woo J, Tsang MK, Tse RK. Visualization of anterior chamber angle dynamics using optical coherence tomography. Ophthalmology 2005 Jun;112(6):980-984.
  4. Leung DY, Lam DK, Yeung BY, Lam DS. Comparison between central corneal thickness measurements by ultrasound pachymetry and optical coherence tomography. Clin Experiment Ophthalmol 2006 Nov;34(8):751-754.
  5. Madgula IM, Kotta S. Stratus optical coherence tomogram III: A novel, reliable and accurate way to measure corneal thickness. Indian J Ophthalmol 2007 Jul-Aug;55(4):301-303.
  6. Wirbelauer C, Scholz C, Hoerauf H, Engelhardt R, Birngruber R, Laqua H. Corneal optical coherence tomography before and immediately after excimer laser photorefractive keratectomy. Am J Ophthalmol 2000 Dec;130(6):693-699.
  7. Wong AC, Wong CC, Yuen NS, Hui SP. Correlational study of central corneal thickness measurements on Hong Kong Chinese using optical coherence tomography, Orbscan and ultrasound pachymetry. Eye (Lond) 2002 Nov;16(6):715-721.
  8. Dorairaj S, Liebmann JM, Ritch R. Quantitative evaluation of anterior segment parameters in the era of imaging. Trans Am Ophthalmol Soc 2007;105:99-108.
  9. Nolan WP, See JL, Chew PT, Friedman DS, Smith SD, Radhakrishnan S, Zheng C, Foster PJ, Aung T. Detection of primary angle closure using anterior segment optical coherence tomography in Asian eyes. Ophthalmology 2007 Jan;114(1):33-39.
  10. Hangai M, Ojima Y, Gotoh N, Inoue R, Yasuno Y, Makita S, Yamanari M, Yatagai T, Kita M, Yoshimura N. Three-dimensional imaging of macular holes with high-speed optical coherence tomography. Ophthalmology 2007 Apr;114(4): 763-773.
  11. Ojima Y, Hangai M, Sasahara M, Gotoh N, Inoue R, Yasuno Y, Makita S, Yatagai T, Tsujikawa A, Yoshimura N. Threedimensional imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography. Ophthalmology 2007 Dec;114(12):2197-2207.
  12. Srinivasan VJ, Wojtkowski M, Witkin AJ, Duker JS, Ko TH, Carvalho M, Schuman JS, Kowalczyk A, Fujimoto JG. Highdefinition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography. Ophthalmology 2006 Nov;113(11): 2054-2014.
  13. Foster PJ, Johnson GJ. Glaucoma in China: how big is the problem? Br J Ophthalmol 2001 Nov;85(11):1277-1282.
  14. Spaeth GL, Aruajo S, Azuara A. Comparison of the configuration of the human anterior chamber angle, as determined by the Spaeth gonioscopic grading system and ultrasound biomicroscopy. Trans Am Ophthalmol Soc 1995;93:337-347.
  15. Spaeth GL, Azuara-Blanco A, Araujo SV, Augsburger JJ. Intraobserver and interobserver agreement in evaluating the anterior chamber angle configuration by ultrasound biomicroscopy. J Glaucoma 1997 Feb;6(1):13-17.
  16. Pavlin CJ, Harasiewicz K, Foster FS. Ultrasound biomicroscopy of anterior segment structures in normal and glaucomatous eyes. Am J Ophthalmol 1992 Apr;113(4):381-389.
  17. Ishikawa H, Liebmann JM, Ritch R. Quantitative assessment of the anterior segment using ultrasound biomicroscopy. Curr Opin Ophthalmol 2000 Apr;11(2):133-139.
  18. Radhakrishnan S, Goldsmith J, Huang D, Westphal V, Dueker DK, Rollins AM, Izatt JA, Smith SD. Comparison of optical coherence tomography and ultrasound biomicroscopy for detection of narrow anterior chamber angles. Arch Ophthalmol 2005 Aug;123(8):1053-1059.
  19. Sakata LM, Lavanya R, Friedman DS, Aung HT, Seah SK, Foster PJ, Aung T. Assessment of the scleral spur in anterior segment optical coherence tomography images. Arch Ophthalmol 2008 Feb;126(2):181-185.
  20. Li H, Leung CK, Cheung CY, Wong L, Pang CP, Weinreb RN, Lam DS. Repeatability and reproducibility of anterior chamber angle measurement with anterior segment optical coherence tomography. Br J Ophthalmol 2007 Nov;91(11):1490-1492.
  21. Woo EK, Pavlin CJ, Slomovic A, Taback N, Buys YM. Ultrasound biomicroscopic quantitative analysis of light-dark changes associated with pupillary block. Am J Ophthalmol 1999 Jan;127(1):43-47.
  22. Leung CK, Cheung CY, Li H, Dorairaj S, Yiu CK, Wong AL, Liebmann J, Ritch R, Weinreb R, Lam DS. Dynamic analysis of dark-light changes of the anterior chamber angle with anterior segment OCT. Invest Ophthalmol Vis Sci 2007 Sep;48(9):4116- 4122.
  23. Muller M, Dahmen G, Porksen E, Geerling G, Laqua H, Ziegler A, Hoerauf H. Anterior chamber angle measurement with optical coherence tomography: Intraobserver and interobserver variability. J Cataract Refract Surg 2006 Nov;32(11):1803-1808.
  24. Urbak SF. Ultrasound biomicroscopy. I. Precision of measurements. Acta Ophthalmol Scand 1998 Aug;76(4):447-455.
  25. Wirbelauer C, Karandish A, Haberle H, Pham DT. Noncontact goniometry with optical coherence tomography. Arch Ophthalmol 2005 Feb;123(2):179-185.
  26. Dada T, Sihota R, Gadia R, Aggarwal A, Mandal S, Gupta V. Comparison of anterior segment optical coherence tomography and ultrasound biomicroscopy for assessment of the anterior segment. J Cataract Refract Surg 2007 May;33(5):837-840.
  27. Leung CK, Li H, Weinreb RN, Liu J, Cheung CY, Lai RY, Pang CP, Lam DS. Anterior chamber angle measurement with anterior segment optical coherence tomography: A comparison between slit lamp OCT and Visante OCT. Invest Ophthalmol Vis Sci 2008 Aug;49(8):3469-3474.
  28. Devereux JG, Foster PJ, Baasanhu J, Uranchimeg D, Lee PS, Erdenbeleig T, Machin D, Johnson GJ, Alsbirk PH. Anterior chamber depth measurement as a screening tool for primary angle-closure glaucoma in an East Asian population. Arch Ophthalmol 2000 Feb;118(2):257-263.
  29. Mandell MA, Pavlin CJ, Weisbrod DJ, Simpson ER. Anterior chamber depth in plateau iris syndrome and pupillary block as measured by ultrasound biomicroscopy. Am J Ophthalmol 2003 Nov;136(5):900-903.
  30. Baikoff G, Jitsuo Jodai H, Bourgeon G. Measurement of the internal diameter and depth of the anterior chamber: IOLMaster versus anterior chamber optical coherence tomographer. J Cataract Refract Surg 2005 Sep;31(9):1722-1728.
  31. Fontana ST, Brubaker RF. Volume and depth of the anterior chamber in the normal aging human eye. Arch Ophthalmol 1980 Oct;98(10):1803-1808.
  32. Lee DA, Brubaker RF, Ilstrup DM. Anterior chamber dimensions in patients with narrow angles and angle-closure glaucoma. Arch Ophthalmol 1984 Jan;102(1):46-50.
  33. Wang N, Wang B, Zhai G, Lei K, Wang L, Congdon N. A method of measuring anterior chamber volume using the anterior segment optical coherence tomographer and specialized software. Am J Ophthalmol 2007 May;143(5):879-881.
  34. Lei K, Wang N, Wang L, Wang B. Morphological changes of the anterior segment after laser peripheral iridotomy in primary angle closure. Eye (Lond) 2009 Feb;23(2):345-350.
  35. Avitabile T, Russo V, Uva MG, Marino A, Castiglione F, Reibaldi A. Ultrasound-biomicroscopic evaluation of filtering blebs after laser suture lysis trabeculectomy. Ophthalmologica 1998;212(Suppl 1):17-21.
  36. McWhae JA, Crichton AC. The use of ultrasound biomicroscopy following trabeculectomy. Can J Ophthalmol 1996 Jun;31(4):187-191.
  37. Munnich S, Lieb WE, Jahn R, Grehn F. Ultrasound biomicroscopy findings in various forms of glaucoma. Ophthalmologe 1995 Aug;92(4):526-530.
  38. Labbe A, Dupas B, Hamard P, Baudouin C. In vivo confocal microscopy study of blebs after filtering surgery. Ophthalmology 2005 Nov;112(11):1979-1986.
  39. Leung CK, Yick DW, Kwong YY, Li FC, Leung DY, Mohamed S, Tham CC, Chung-chai C, Lam DS. Analysis of bleb morphology after trabeculectomy with Visante anterior segment optical coherence tomography. Br J Ophthalmol 2007 Mar;91(3):340- 344.
  40. Singh M, Chew PTK, Friedman DS, Nolan WP, See JL, Smith SD, Zheng C, Foster PJ, Aung T. Imaging of trabeculectomy blebs using anterior segment optical coherence tomography. Ophthalmology 2007 Jan;114(1):47-53.
  41. Ciancaglini M, Carpineto P, Agnifili L, Nubile M, Lanzini M, Fasanella V, Mastropasqua L. Filtering bleb functionality: A clinical, anterior segment optical coherence tomography and in vivo confocal microscopy study. J Glaucoma 2008 Jun- Jul;17(4):308-317.
  42. Theelen T, Wesseling P, Keunen JE, Klevering BJ. A pilot study on slit lamp-adapted optical coherence tomography imaging of trabeculectomy filtering blebs. Graefes Arch Clin Exp Ophthalmol 2007 Jun;245(6):877-882.
  43. Singh M, See JL, Aquino MC, Thean LS, Chew PT. High-definition imaging of trabeculectomy blebs using spectral domain optical coherence tomography adapted for the anterior segment. Clin Experiment Ophthalmol 2009 May;37(4):345-351.
  44. Tominaga A, Miki A, Yamazaki Y, Matsushita K, Otori Y. The assessment of the filtering bleb function with anterior segment optical coherence tomography. J Glaucoma 2010 Oct- Nov;19(8):551-555.
  45. Pfenninger L, Schneider F, Funk J. Internal reflectivity of filtering blebs versus intraocular pressure in patients with recent trabeculectomy. Invest Ophthalmol Vis Sci 2011 Apr 14;52(5):2450-2455.
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