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VOLUME 10 , ISSUE 1 ( January-April, 2016 ) > List of Articles

REVIEW ARTICLE

The Suprachoroidal Route in Glaucoma Surgery

Anthony Gigon, Tarek Shaarawy

Keywords : Glaucoma surgery, Microinvasive, Review, Suprachoroidal

Citation Information : Gigon A, Shaarawy T. The Suprachoroidal Route in Glaucoma Surgery. J Curr Glaucoma Pract 2016; 10 (1):13-20.

DOI: 10.5005/jp-journals-10008-1197

License: CC BY-NC 4.0

Published Online: 01-08-2019

Copyright Statement:  Copyright © 2016; The Author(s).


Abstract

Glaucoma surgeries targeting the uveoscleral drainage pathways have been drawing more attention lately. Among all the available techniques, procedures focusing on the supra-choroidal space seem particularly promising, by making use of a presumably efficient and secure outflow route and avoiding subconjunctival filtration blebs. The purpose of this review is to assess the efficacy and the security of the different suprachoroidal drainage implants, namely the CyPass Micro-Stent, the iStent Supra, the SOLX Gold Shunt, the Aquashunt, and the STARflo Glaucoma Implant. Most clinical studies seem to currently point toward the direction that there are actual benefits in suprachoroidal surgeries by avoiding bleb-related complications. Nevertheless, even suprachoroidal implants may be subject to scarring and failure. More data are still needed, especially concerning long-term effects, although the approach does seem appealing.

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  1. Schnyder C, Mermoud A, Roy S. Physiologie et dynamique de l'humeur aqueuse. Glaucome, Elsevier; 2005. p. 36-43.
  2. Nilsson SF. The uveoscleral outflow routes. Eye Lond Engl 1997;11(Pt 2):149-154.
  3. Emi K, Pederson JE, Toris CB. Hydrostatic pressure of the suprachoroidal space. Invest Ophthalmol Vis Sci 1989 Feb; 30(2):233-238.
  4. Bill A. Effects of atropine and pilocarpine on aqueous humour dynamics in cynomolgus monkeys (Macaca irus). Exp Eye Res 1967 Apr;6(2):120-125.
  5. Bill A, Phillips CI. Uveoscleral drainage of aqueous humour in human eyes. Exp Eye Res 1971 Nov;12(3):275-281.
  6. Toris CB, Yablonski ME, Wang YL, Camras CB. Aqueous humor dynamics in the aging human eye. Am J Ophthalmol 1999 Apr;127(4):407-412.
  7. Toris CB, Koepsell SAB, Yablonski ME, Camras CB. Aqueous humor dynamics in ocular hypertensive patients. J Glaucoma 2002 Jun;11(3):253-258.
  8. Yablonski ME, Cook DJ, Gray J. A fluorophotometric study of the effect of argon laser trabeculoplasty on aqueous humor dynamics. Am J Ophthalmol 1985 May 1;99(5): 579-582.
  9. Crawford K, Kaufman PL. Pilocarpine antagonizes prostaglandin F2 alpha-induced ocular hypotension in monkeys. Evidence for enhancement of Uveoscleral outflow by prostaglandin F2 alpha. Arch Ophthalmol 1987 Aug; 105(8):1112-1116.
  10. Nilsson SFE, Samuelsson M, Bill A, Stjernschantz J. Increased uveoscleral outflow as a possible mechanism of ocular hypotension caused by prostaglandin F2ƒ¿-1-isopropylester in the cynomolgus monkey. Exp Eye Res 1989 May;48(5):707-716.
  11. Ocklind A. Effect of latanoprost on the extracellular matrix of the ciliary muscle: a study on cultured cells and tissue sections. Exp Eye Res 1998 Aug;67(2):179-191.
  12. Sagara T, Gaton DD, Lindsey JD, Gabelt BT, Kaufman PL, Weinreb RN. Topical prostaglandin F2alpha treatment reduces collagen types I, III and IV in the monkey uveoscleral outflow pathway. Arch Ophthalmol 1999 Jun;117(6):794-801.
  13. Crowston JG, Lindsey JD, Aihara M, Weinreb RN. Effect of Latanoprost on intraocular pressure in mice lacking the prostaglandin FP receptor. Invest Ophthalmol Vis Sci 2004 Oct 1;45(10):3555-3559.
  14. Crowston JG, Lindsey JD, Morris CA, Wheeler L, Medeiros FA, Weinreb RN. Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout mice. Invest Ophthalmol Vis Sci 2005 Dec 1;46(12):4571-4577.
  15. Weinreb RN, Toris CB, Gabelt BT, Lindsey JD, Kaufman PL. Effects of prostaglandins on the aqueous humor outflow pathways. Surv Ophthalmol 2002 Aug; 47:S53-S64.
  16. Sambhara D, Aref AA. Glaucoma management: relative value and place in therapy of available drug treatments. Ther Adv Chronic Dis 2014 Jan;5(1):30-43.
  17. Van der Valk R, Webers CAB, Schouten JSAG, Zeegers MP, Hendrikse F, Prins MH. Intraocular pressure-lowering effects of all commonly used glaucoma drugs: a meta-analysis of randomized clinical trials. Ophthalmol 2005 Jul;112(7): 1177-1185.
  18. Hoeh H, Ahmed IIK, Grisanti S, Grisanti S, Grabner G, Nguyen QH, et al. Early postoperative safety and surgical outcomes after implantation of a suprachoroidal micro-stent for the treatment of open-angle glaucoma concomitant with cataract surgery. J Cataract Refract Surg 2013 Mar;39(3): 431-437.
  19. Hoeh H, Vold SD, Ahmed IK, Anton A, Rau M, Singh K, et al. Initial clinical experience with the CyPass Micro-Stent: safety and surgical outcomes of a novel supraciliary microstent. J Glaucoma 2014 Oct 9.
  20. Grisanti S, Margolina E, Hoeh H, Rau M, Erb C, Kersten- Gomez I, et al. [Supraciliary microstent for open-angle glaucoma: clinical results of a prospective multicenter study]. Ophthalmol Z Dtsch Ophthalmol Ges 2014 Jun;111(6):548-552.
  21. Hoh H, Grisanti S, Grisanti S, Rau M, Ianchulev S. Two-year clinical experience with the CyPass micro-stent: safety and surgical outcomes of a novel supraciliary micro-stent. Klin Monatsblatter Fur Augenheilkd 2014 Apr;231(4):377-381.
  22. Junemann A. Twelve-month outcomes following ab interno implantation of suprachoroidal stent and postoperative administration of travoprost to treat open angle glaucoma. Amsterdam; 2013. Available from: http://escrs.org/amsterdam2013/programme/posters-details.asp?id=19512
  23. Melamed S, Ben Simon GJ, Goldenfeld M, Simon G. Efficacy and safety of gold micro shunt implantation to the supraciliary space in patients with glaucoma: a pilot study. Arch Ophthalmol 2009 Mar;127(3):264-269.
  24. Francis BA, Singh K, Lin SC, Hodapp E, Jampel HD, Samples JR, et al. Novel glaucoma procedures: a report by the American Academy of Ophthalmology. Ophthalmol 2011;118(7):1466-1480.
  25. Figus M, Lazzeri S, Fogagnolo P, Iester M, Martinelli P, Nardi M. Supraciliary shunt in refractory glaucoma. Br J Ophthalmol 2011 Nov;95(11):1537-1541.
  26. Brandão LM, Grieshaber MC. Update on minimally invasive glaucoma surgery and new implants. J Ophthalmol [Internet]. 2013 [cited 2015 Apr 9];2013. Available at: http://www.ncbi. nlm.nih.gov/pmc/articles/PMC3863473/
  27. Hueber A, Roters S, Jordan JF, Konen W. Retrospective analysis of the success and safety of gold micro shunt implantation in glaucoma. BMC Ophthalmol 2013;13:35.
  28. Mastropasqua L, Agnifili L, Ciancaglini M, Nubile M, Carpineto P, Fasanella V, et al. In vivo analysis of conjunctiva in gold micro shunt implantation for glaucoma. Br J Ophthalmol 2010 Dec;94(12):1592-1596.
  29. Skaat A, Sagiv O, Kinori M, Simon GJB, Goldenfeld M, Melamed S. Gold micro-shunt implants versus Ahmed glaucoma valve: long-term outcomes of a prospective randomized clinical trial. J Glaucoma 2014 Oct 14.
  30. Agnifili L, Costagliola C, Figus M, Iezzi G, Piattelli A, Carpineto P, et al. Histological findings of failed gold micro shunts in primary open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol 2011 Aug 23;250(1):143-149.
  31. Berk TA, Tam DY, Werner L, Mamalis N, Ahmed IIK. Electron microscopic evaluation of a gold glaucoma micro shunt after explantation. J Cataract Refract Surg 2015 Mar;41(3):674-680.
  32. Pourjavan S, Collignon N, De Groot V. STARfloTM Glaucoma Implant: 12 month clinical results. Acta Ophthalmol (Copenh) 2013 Aug:91.
  33. Azuara-Blanco A, Katz LJ. Dysfunctional filtering blebs. Surv Ophthalmol 1998 Sep;43(2):93-126.
  34. Vijaya L, Manish P, Ronnie G, Shantha B. Management of complications in glaucoma surgery. Ind J Ophthalmol 2011 Jan;59(Suppl 1):S131-S140.
  35. Shaarawy TM, Sherwood MB, Hitchings RA, Crowston JG. Devices in development and new procedures. In: Glaucoma Medical Diagnosis & Therapy. Elsevier. 2015.
  36. Available from: https://clinicaltrials.gov/ct2/show/NCT01085357.
  37. Available from: http://new-glaucoma-treatments.com/glaukos-istent-supra-fda-approval/.
  38. Available from: http://ophthalmologytimes.modernmedicine. com/ophthalmologytimes/content/tags/2014-glaucoma-360/migs-driving-device-market?page=full.
  39. Available from: http://www.solx.com/content/history.
  40. Available from: https://clinicaltrials.gov/show/NCT00834223.
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