Journal of Current Glaucoma Practice

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VOLUME 9 , ISSUE 1 ( January-April, 2015 ) > List of Articles

Original Article

Ocular Perfusion Pressure and Pulsatile Ocular Blood Flow in Normal and Systemic Hypertensive Patients

Fabio N Kanadani, Carlos R Figueiredo, Rafaela Morais Miranda, Patricia LT Cunha, Tereza Cristina M Kanadani, Syril Dorairaj

Keywords : Ocular perfusion pressure, Pulsatile ocular blood flow, Glaucoma

Citation Information : Kanadani FN, Figueiredo CR, Miranda RM, Cunha PL, M Kanadani TC, Dorairaj S. Ocular Perfusion Pressure and Pulsatile Ocular Blood Flow in Normal and Systemic Hypertensive Patients. J Curr Glaucoma Pract 2015; 9 (1):16-19.

DOI: 10.5005/jp-journals-10008-1177

License: CC BY-NC 4.0

Published Online: 01-04-2015

Copyright Statement:  Copyright © 2015; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Purpose: Glaucomatous neuropathy can be a consequence of insufficient blood supply, increase in intraocular pressure (IOP), or other risk factors that diminish the ocular blood flow. To determine the ocular perfusion pressure (OPP) in normal and systemic hypertensive patients. Materials and methods: One hundred and twenty-one patients were enrolled in this prospective and comparative study and underwent a complete ophthalmologic examination including slit lamp examination, Goldmann applanation tonometry, stereoscopic fundus examination, and pulsatile ocular blood flow (POBF) measurements. The OPP was calculated as being the medium systemic arterial pressure (MAP) less the IOP. Only right eye values were considered for calculations using Student\'s t-test. Results: The mean age of the patients was 57.5 years (36-78), and 68.5% were women. There was a statistically significant difference in the OPP of the normal and systemic hypertensive patients (p < 0.05). The difference in the OPP between these groups varied between 8.84 and 17.9 mm Hg. Conclusion: The results of this study suggest that although the systemic hypertensive patients have a higher OPP in comparison to normal patients, this increase does not mean that they also have a higher OBF (as measured by POBF tonograph). This may be caused by chronic changes in the vascular network and in the blood hemodynamics in patients with systemic hypertension.


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  1. Flammer J, Orgul S, Costa VP, Orzalesi N, Krieglstein GK, Serra LM, Renard JP, Stefánsson E. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res 2002 Jul;21(4):359-393.
  2. Aydin A, Wollstein G, Price LL, Schuman JS. Evaluating pulsatile ocular blood flow analysis in normal and treated glaucomatous eyes. Am J Ophthalmol 2003 Sep;136(3):448-453.
  3. Hayreh, SS. Blood supply of the optic nerve head: a ‘reality check’. In: Pillunat LE, Harris A, Anderson DR, Greve EL, editors. Current Concepts on Ocular Blood Flow in Glaucoma. The Hague, The Netherlands: Kugler Publications,1999. p.3-31.
  4. Singleton CD, Robertson D, Byrne DW, Joos KM. Effect of posture on blood and intraocular pressures in multiple system atrophy, pure autonomic failure, and baroreflex failure. Circulation 2003 Nov 11;108(19):2349-2354.
  5. Leske MC, Wu SY, Nemesure B, Hennis A. Incident openangle glaucoma and blood pressure. Arch Ophthalmol 2002 Jul;120(7):954-959.
  6. James CB. Pulsatile ocular blood flow. Br J Ophthalmol 1998 Jul;82(7):720-721.
  7. Ocular Blood Flow Tonometer. User's manual: OBF Labs (UK) Ltd.
  8. OBF Labs homepage. http://www.cix.co.uk/~obf-labs/welcome.htm. Accessed on January 20, 2015.
  9. Silver DM, Farrell RA, Langham ME, O'Brien V, Schilder P. Estimation of pulsatile ocular blood flow from intraocular pressure. Acta Ophthalmol Suppl 1989;191:25-29.
  10. Kanadani FK, Ribeiro BB, Suzuki ERJ, R FC, Duarte WB. Influency of the tropicamide 1% in the central corneal thickness. J Opthalmol 2004;63:447-451.
  11. Fuchsjäger-Mayrl G, Wally B, Georgopoulos M, Rainer G, Kircher K, Buehl W, Amoako-Mensah T, Eichler HG, Vass C, Schmetterer L. Ocular blood flow and systemic blood pressure in patients with primary open-angle glaucoma and ocular hypertension. Invest Ophthalmol Vis Sci 2004 Mar;45(3):834-839.
  12. Sehi M, Flanagan JG, Zeng L, Cook RJ, Trope GE. Relative change in diurnal mean ocular perfusion pressure: a risk factor for the diagnosis of primary open-angle glaucoma. Invest Ophthalmol Vis Sci 2005 Feb;46(2):561-567.
  13. Weigert G, Findl O, Luksch A, Rainer G, Kiss B, Vass C, Schmetterer L. Effects of moderate changes in intraocular pressure on ocular hemodynamics in patients with primary open-angle glaucoma and healthy controls. Ophthalmology 2005 Aug;112(8):1337-1342.
  14. Yang YC, Hulbert MF, Batterbury M, Clearki n LG. Pulsatile ocular blood flow measurements in healthy eyes: reproducibility and reference values. J Glaucoma 1997 Jun;6(3):175-179.
  15. Geyer O, Silver DM, Mathalon N, Massey AD. Gender and age effects on pulsatile ocular blood flow. Ophthalmic Res 2003 Sep-Oct;35(5):247-250.
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