Pseudoexfoliation (PXF) syndrome is a well-recognized clinical entity of considerable clinical significance. It is associated with poor mydriasis, cataracts with weak zonular support, secondary glaucoma and possibly with biochemical abnormalities, such as elevated homocysteine and systemic diseases involving the cardiovascular and central nervous system. There have also been some recent studies identifying mutations in genes which are associated with PXF.
Vessani RM, Ritch R, Liebmann JM, Jofe M. Plasma homocysteine is elevated in patients with exfoliation syndrome. Am J Ophthalmol 2003 Jul;136(1):41-46.
Prince AM, Ritch R. Clinical signs of the pseudoexfoliation syndrome. Ophthalmology 1986 Jun;93(6):803-807.
Puska P, Vasara K, Harju M, Setälä K. Corneal thickness and corneal endothelium in normotensive subjects with unilateral exfoliation syndrome. Graefes Arch Clin Exp Ophthalmol 2000 Aug;238(8):659-663.
Naumann GO, Schlötzer-Schrehardt U. Keratopathy in pseudoexfoliation syndrome as a cause of corneal endothelial decompensation: a clinicopathologic study. Ophthalmology 2000 Jun;107(6):1111-1124.
Pohjanpelto P. Long-term prognosis of visual field in glaucoma simplex and glaucoma capsular. Acta Ophthalmol (Copenh) 1985 Aug;63(4):418-423.
Vesti E, Kivelä T. Exfoliation syndrome and exfoliation glaucoma. Prog Retin Eye Res 2000 May;19(3):345-368.
Yarangümeli A, Davutluoglu B, Köz OG, Elhan AH, Yaylaci M, Kural G. Glaucomatous damage in normotensive fellow eyes of patients with unilateral hypertensive pseudoexfoliation glaucoma: normotensive pseudoexfoliation glaucoma? Clin Experiment Ophthalmol 2006 Jan-Feb;34(1):15-19.
Schlötzer-Schrehardt U, Koca MR, Naumann GO, Volkholz H. Pseudoexfoliation syndrome. Ocular manifestation of a systemic disorder? Arch Ophthalmol 1992 Dec;110(12):1752-1756.
Mitchell P, Wang JJ, Smith W. Association of pseudoexfoliation with increased vascular risk. Am J Ophthalmol 1997 Nov;124(5): 685-687.
