Journal of Current Glaucoma Practice

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VOLUME 7 , ISSUE 2 ( May-August, 2013 ) > List of Articles

CASE REPORT

An Overlap Syndrome of Pigment Dispersion and Pigmentary Glaucoma accompanied by Marfan Syndrome: Case Report with Literature Review

Tutul Chakravarti, George Spaeth

Keywords : Pigmentary glaucoma, Pigment dispersion syndrome, Marfan syndrome, Ectopia lentis, Intraocular pressure fluctuation, Reverse pupillary block, Exfoliation syndrome

Citation Information : Chakravarti T, Spaeth G. An Overlap Syndrome of Pigment Dispersion and Pigmentary Glaucoma accompanied by Marfan Syndrome: Case Report with Literature Review. J Curr Glaucoma Pract 2013; 7 (2):91-95.

DOI: 10.5005/jp-journals-10008-1143

License: CC BY-NC 4.0

Published Online: 00-08-2013

Copyright Statement:  Copyright © 2013; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

‘Overlap syndrome’ describes the situation in which two or more ‘independent’ conditions are present, either one of which could cause a particular finding. This current presentation reports a case with bilateral pigment dispersion syndrome (PDS), advanced pigmentary glaucoma (PG), and the Marfan syndrome, with bilateral subluxation of the lenses, and large short-term and long-term fluctuations of intraocular pressure. It is interesting to consider whether the associated advanced glaucomatous nerve damage could be a manifestation of just the PDS, just the Marfan syndrome, or rather a combination of these two overlapping independent conditions.


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  1. Allingham, RR.; Damji, KF.; Freedman, SF, et al. Shields textbook of glaucoma. 6th ed. Philadelphia, PA, USA: Wolters Kluwer/Lippincott Williams & Wilkins; 2011. p. 303.
  2. Doyle A, Hamard P, Puech M, Lachkar Y. Asymmetric pigmentary glaucoma in a patient with Marfan's syndrome. Graefes Arch Clin Exp Ophthalmol 2005 Sep;243(9):955-957.
  3. Andersen JS, Pralea AM, DelBono EA, Haines JL, Gorin MB, Schuman JS, Mattox CG, Wiggs JL. A gene responsible for the pigment dispersion syndrome maps to chromosome 7q35- q36. Arch Ophthalmol 1997 Mar;115(3):384-388.
  4. Kaiser-Kupfer MI, Kupfer C, McCain L. Asymmetric pigment dispersion syndrome. Trans Am Ophthalmol Soc 1983;81:310-322.
  5. Scheie HS, Cameron JD. Pigment dispersion syndrome: a clinical study. Br J Ophthalmol 1981 Apr;65(4):264-269.
  6. Rodrigues MM, Spaeth GL, Weinreb S, Sivalingam E. Spectrum of trabecular pigmentation in open-angle glaucoma: a clinico-pathologic study. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol 1976 Mar-Apr;81(2):258-276.
  7. Karickhoff JR. Pigmentary dispersion syndrome and pigmentary glaucoma: a new mechanism concept, a new treatment and a new technique. Ophthalmic Surg 1992 Apr;23(4):269-277.
  8. Migliazzo CV, Shaffer RN, Nykin R, Magee S. Long-term analysis of pigmentary dispersion and pigmentary glaucoma. Ophthalmology 1986 Dec;93(12):1528-1536.
  9. Richter CU, Richardson TM, Grant WM. Pigmentary dispersion syndrome and pigmentary glaucoma. A prospective study of the natural history. Arch Ophthalmol 1986 Feb;104(2):211-215.
  10. Maumenee IH. The eye in the Marfan syndrome. Trans Am Ophthalmol Soc 1981;79:684-733.
  11. Kainulainen K, Pulkkinen L, Savolainen A, Kaitila I, Peltonen L. Location on chromosome 15 of the gene defect causing Marfan syndrome. N Engl J Med 1990 Oct;323(14): 935-939.
  12. Challa P, Hauser MA, Luna CC, Freedman SF, Pericak-Vance M, Yang J, McDonald MT, Allingham RR. Juvenile bilateral lens dislocation and glaucoma associated with a novel mutation in fibrillin 1 gene. Mol Vis 2006 Aug;12:1009-1015.
  13. Jarrett WH II. Dislocation of the lens. A study of 166 hospitalized cases. Arch Ophthalmol 1967 Sep;78(3):289-296.
  14. Izquierdo NJ, Traboulsi EI, Enger C, Maumenee IH. Glaucoma in the Marfan syndrome. Trans Am Ophthalmol Soc 1992;90:111-122.
  15. Mudumbai R, Libermann JM, Ritch R. Combined exfoliation and pigment dispersion: an overlap syndrome. Trans Am Ophthalmol Soc 1999;97:297-321.
  16. Layden WE, Ritch R, King DG, Teekhasaenee C. Combined exfoliation and pigment dispersion syndromes. Am J Ophthalmol 1990 May;109(5):530-534.
  17. Haynes WL, Thompson HS, Kardon RH, Alward WL. Asymmetric pigmentary dispersion syndrome mimicking Horner's syndrome. Am J Ophthalmol 1991 Oct;112(4):463-464.
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