Pattern Electroretinography Changes in Patients with Established or Suspected Primary Open Angle Glaucoma
Sunil Ganekal, Syril Dorairaj, Vishal Jhanji
Pattern ERG, Primary open angle glaucoma, Glaucoma suspects
Citation Information :
Ganekal S, Dorairaj S, Jhanji V. Pattern Electroretinography Changes in Patients with Established or Suspected Primary Open Angle Glaucoma. J Curr Glaucoma Pract 2013; 7 (2):39-42.
Purpose: To assess pattern electroretinogram (PERG) changes in patients with established or suspected primary open angle glaucoma (POAG).
Materials and methods: Transient PERG using LV Prasad eye electrodes were performed in 76 normal, 32 glaucomatous and 22 glaucoma suspect eyes. The P50 amplitude, N95 amplitude and P50 latency were analyzed. The results were further analyzed with receiver operating characteristic (ROC) curves and discriminant function analysis (DFA).
Results: The P50 and N95 amplitude of the POAG and glaucoma suspect groups were significantly reduced. There was significant shortening in the P50 latency in the POAG and glaucoma suspect groups. DFA using the P50 amplitude, N95 amplitude and P50 latency waveform parameters showed a sensitivity and specificity of 76.67 and 88.57% respectively.
Conclusion: Pattern ERG demonstrated significant changes in POAG patients and suspects. ROC curves for the three wave parameters demonstrated that N95 amplitude was the better indicator for diagnosis of POAG when used individually.
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