A Comfort Survey of Timolol Hemihydrate 0.5% Solution Once or Twice Daily vs Timolol Maleate in Sorbate

William C Stewart; Jeffrey C Oehler; Neil T Choplin; Joseph I Markoff; Marlene R Moster; Parul Ichhpujani; Lindsay A Nelson

doi:10.5005/jp-journals-10008-1130

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A Comfort Survey of Timolol Hemihydrate 0.5% Solution Once or Twice Daily vs Timolol Maleate in Sorbate

William C Stewart, Jeffrey C Oehler, Neil T Choplin, Joseph I Markoff, Marlene R Moster, Parul Ichhpujani, Lindsay A Nelson

Keywords : Betimol, Comfort, Glaucoma, Istalol, Timolol hemihydrate, Timolol maleate with potassium sorbate

Citation Information : Stewart WC, Oehler JC, Choplin NT, Markoff JI, Moster MR, Ichhpujani P, Nelson LA. A Comfort Survey of Timolol Hemihydrate 0.5% Solution Once or Twice Daily vs Timolol Maleate in Sorbate. J Curr Glaucoma Pract 2013; 7 (1):11-16.

DOI: 10.5005/jp-journals-10008-1130

License: CC BY-NC 4.0

Published Online: 01-04-2018

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Abstract

Objective: To evaluate by survey the comfort upon instillation of timolol hemihydrate compared to timolol maleate with potassium sorbate. Design: A prospective, multicenter, observational, non-interventional study. Participants: One hundred and three patients of open-angle glaucoma or ocular hypertension who were ≥21 years old and were currently prescribed timolol hemihydrate (once or twice daily) or timolol maleate with potassium sorbate once daily as monotherapy or as a part of two-drug therapy. Materials and methods: Study was performed at seven clinical sites in the United States. Patients were surveyed on comfort upon instillation of timolol hemihydrate compared to timolol maleate with potassium sorbate. Results: A difference between timolol hemihydrate and timolol maleate with potassium sorbate for questions 1 (burning/stinging on instillation, p < 0.001) and 4 (tearing on instillation, p = 0.024) was noted. There were no differences between treatment groups for any other question (p > 0.05). Conclusion: This survey suggests that timolol hemihydrate is associated with less stinging/burning and tearing than timolol maleate with potassium sorbate.

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DuBiner HB, Hill R, Kaufman H, Keates EU, Zimmerman TJ, Mandell AI, Mundorf TK, Bahr RL, Schwartz LW, Towey AW. Timolol hemihydrate vs timolol maleate to treat ocular hypertension and open-angle glaucoma. Am J Ophthalmol 1996 May;121(5):522-528.
Mundorf TK, Cate EA, Sine CS, Otero DW, Stewart JA, Stewart WC. The safety and efficacy of switching timolol maleate 0.5% solution to timolol hemihydrate 0.5% solution given twice daily. J Ocul Pharmacol Ther 1998 Apr;14(2):129-135.
Stewart WC, Day DG, Sharpe ED, Dubiner HB, Holmes KT, Stewart JA. Efficacy and safety of timolol solution once daily vs timolol gel added to latanoprost. Am J Ophthalmol 1999 Dec;128(6):692-696.
Mundorf TK, Ogawa T, Inui N, Naka H, Novack GD, Crockett RS. Timolol LA: a double-masked, active-controlled, randomized, crossover, comfort, ocular safety and systemic bioavailability study in healthy volunteers. Curr Med Res Opin 2005 Mar;21(3):369-374.
Mundorf TK, Ogawa T, Naka H, Novack GD, Crockett RS. A 12-month, multicenter, randomized, double-masked, parallelgroup comparison of timolol-LA once daily and timolol maleate ophthalmic solution twice daily in the treatment of adults with glaucoma or ocular hypertension. Clin Ther 2004 Apr;26(4): 541-551.
Book, SA. Essentials of Statistics. New York: McGraw-Hill Inc; 1978.
Stewart WC, Stewart JA, Holmes KT, Leech JN. Differences in ocular surface irritation between timolol hemihydrate and timolol maleate. Am J Ophthalmol 2000 Dec;130(6):712-716.
Sonty S, Mundorf TK, Stewart JA, Stewart WC. Short-term tolerability of once-daily timolol hemihydrate 0.5%, timolol maleate in sorbate 0.5% and generic timolol maleate gel-forming solution 0.5% in glaucoma and/or ocular hypertension: a prospective, randomized, double-masked, active-controlled, three-period crossover pilot study. Clin Ther 2009 Oct;31(10):2063-2071.

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