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VOLUME 7 , ISSUE 1 ( January-April, 2013 ) > List of Articles
William C Stewart, Jeffrey C Oehler, Neil T Choplin, Joseph I Markoff, Marlene R Moster, Parul Ichhpujani, Lindsay A Nelson
Keywords : Betimol, Comfort, Glaucoma, Istalol, Timolol hemihydrate, Timolol maleate with potassium sorbate
Citation Information : Stewart WC, Oehler JC, Choplin NT, Markoff JI, Moster MR, Ichhpujani P, Nelson LA. A Comfort Survey of Timolol Hemihydrate 0.5% Solution Once or Twice Daily vs Timolol Maleate in Sorbate. J Curr Glaucoma Pract 2013; 7 (1):11-16.
License: CC BY-NC 4.0
Published Online: 01-04-2018
Copyright Statement: Copyright © 2013; The Author(s).
Objective: To evaluate by survey the comfort upon instillation of timolol hemihydrate compared to timolol maleate with potassium sorbate. Design: A prospective, multicenter, observational, non-interventional study. Participants: One hundred and three patients of open-angle glaucoma or ocular hypertension who were ≥21 years old and were currently prescribed timolol hemihydrate (once or twice daily) or timolol maleate with potassium sorbate once daily as monotherapy or as a part of two-drug therapy. Materials and methods: Study was performed at seven clinical sites in the United States. Patients were surveyed on comfort upon instillation of timolol hemihydrate compared to timolol maleate with potassium sorbate. Results: A difference between timolol hemihydrate and timolol maleate with potassium sorbate for questions 1 (burning/stinging on instillation, p < 0.001) and 4 (tearing on instillation, p = 0.024) was noted. There were no differences between treatment groups for any other question (p > 0.05). Conclusion: This survey suggests that timolol hemihydrate is associated with less stinging/burning and tearing than timolol maleate with potassium sorbate.