Journal of Current Glaucoma Practice

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VOLUME 17 , ISSUE 2 ( April-June, 2023 ) > List of Articles

Original Article

Prevalence of Glu323Lys Mutation of the TIGR/MYOC Gene and Risk Factors amongst Primary Open-angle Glaucoma Patients in Ouagadougou, Burkina Faso

Lassina Traoré, Jérôme Sanou, Bélélé S Bakyono, Abdou A Zoure, Théodora M Zohoncon, Hermann K Sombié, Albert T Yonli, Guertrude Meda-Hien, Ezechiel B Tibiri, Florencia W Djigma, Jacques Simpore

Keywords : Burkina Faso, Glu323Lys mutation, Risk factors glaucoma

Citation Information : Traoré L, Sanou J, Bakyono BS, Zoure AA, Zohoncon TM, Sombié HK, Yonli AT, Meda-Hien G, Tibiri EB, Djigma FW, Simpore J. Prevalence of Glu323Lys Mutation of the TIGR/MYOC Gene and Risk Factors amongst Primary Open-angle Glaucoma Patients in Ouagadougou, Burkina Faso. J Curr Glaucoma Pract 2023; 17 (2):79-84.

DOI: 10.5005/jp-journals-10078-1403

License: CC BY-NC 4.0

Published Online: 11-07-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Aim: Glaucoma is a group of degenerative diseases of the optic nerve whose predisposing factors may be genetic. The objective of this study was to estimate the frequency of the Glu323Lys mutation as a genetic risk factor for glaucoma. Materials and methods: A cross-sectional study over 6 months from October 2020 to March 2021 in Ouagadougou, Burkina Faso. A total of 89 samples of patients with primary open-angle glaucoma (POAG) were collected. The frequency of the Glu323Lys mutation of the myocilin, trabecular meshwork inducible glucocorticoid response (TIGR/MYOC) gene by polymerase chain reaction (PCR)—restriction fragment length polymorphism. Results: In glaucoma patients, only homozygous nonmutated guanine-guanine (GG) and heterozygous mutated adenine-guanine (AG) genotypes were found in 96.63 and 3.37% of cases, respectively. Around 69.66% of patients had a family history of glaucoma, 28.09% had a history of hypertension, and 7.86% had a history of diabetes. Conclusion: The frequency of the Glu323Lys mutation of the TIGR/MYOC gene was 3.37% in the glaucoma population in Ouagadougou. A case-control study is necessary to know the contribution of the Glu323Lys mutation as a genetic risk factor for glaucoma in our study population. Clinical significance: This study constituted the beginning of genetic investigations of glaucoma in our context and showed a low Glu323Lys mutation.

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