Journal of Current Glaucoma Practice

Register      Login

VOLUME 16 , ISSUE 1 ( January-April, 2022 ) > List of Articles


Vision-related Quality of Life in Congolese Patients with Glaucoma

Isis K Kapinga, David L Kayembe, Jean-Claude Mwanza

Keywords : Congolese, Glaucoma, NEI VFQ-25, Quality of life

Citation Information : Kapinga IK, Kayembe DL, Mwanza J. Vision-related Quality of Life in Congolese Patients with Glaucoma. J Curr Glaucoma Pract 2022; 16 (1):24-30.

DOI: 10.5005/jp-journals-10078-1360

License: CC BY-NC 4.0

Published Online: 03-05-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Purpose: To assess the vision-related quality of life (QoL) in Congolese patients with glaucoma and its associated factors.
Methods: Ninety-four patients with open-angle glaucoma and 42 age-matched controls were included in the study. QoL was evaluated using the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25). QoL scores were compared between patients and controls. Correlation analysis was run to assess the association of QoL scores with visual function measures. Multivariate linear regression analyses were used to identify demographic and clinical factors that independently predict the overall QoL and its subdomains.
Results: The QoL composite score (QoL-CS) of glaucoma patients (60.2 ± 30.5) was 31.7% lower than that of controls (87.9 ± 9.5), p < 0.001. QoL subdomain scores were also significantly lower in glaucoma patients than controls (all p < 0.001), with a reduction rate oscillating between 16.5% for color vision and 61.1% for general health. Best-corrected visual acuity (BCVA) of both better seeing eye (BSE) and worst seeing eye (WSE) correlated significantly with QoL-CS (variance: 50.4% and 42.3%, respectively). The correlations of QoL-CS with BSE (variance: 12.9%) and WSE (variance: 16.8%) visual field MD were also significant, but the strengths were weaker than those of BCVA. Every increase of BSE's BCVA by one line improved QoL-CS by 43.4.
Conclusion: Vision-related quality of life in glaucoma patients is significantly impaired in Congolese patients with glaucoma, starting in the early stage of the disease. BCVA of the BSE emerged as an independent significant predictor of overall QoL and most of its components.

PDF Share
  1. Kapetanakis VV, Chan MP, Foster PJ, et al. Global variations and time trends in the prevalence of primary open angle glaucoma (POAG): a systematic review and meta-analysis. Br J Ophthalmol 2016;100(1):86–93. DOI: 10.1136/bjophthalmol-2015-307223
  2. Tham YC, Li X, Wong TY, et al. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology 2014;121(11):2081–2090. DOI: 10.1016/j.ophtha.2014.05.013
  3. Kyari F, Abdull MM, Bastawrous A, et al. Epidemiology of glaucoma in sub-Saharan Africa: prevalence, incidence and risk factors. Middle East Afr J Ophthalmol 2013;20(2):111–125. DOI: 10.4103/0974-9233.110605
  4. Kaimbo wa Kaimbo D, Missotten L. Eye diseases and the causes of blindness in the southwestern Equator (equatorial forest) in Zaire, data from an eye camp in three rural centers. Bull Soc Belge Ophtalmol 1997;265:59–65.
  5. Guedes RDP. Quality of life and glaucoma. Rev Bras Oftalmol 2015;74(3):131–132. DOI: 10.5935/0034-7280.20150028
  6. Kaur D, Gupta A, Singh G. Perspectives on quality of life in glaucoma. J Curr Glaucoma Pract 2012;6(1):9–12. DOI: 10.5005/jp-journals-10008-1101
  7. Quaranta L, Riva I, Gerardi C, et al. Quality of life in glaucoma: a review of the literature. Adv Ther 2016;33(6):959–981. DOI: 10.1007/s12325-016-0333-6
  8. Cook C. Glaucoma in Africa: size of the problem and possible solutions. J Glaucoma 2009;18(2):124–128. DOI: 10.1097/IJG.0b013e318189158c
  9. Girkin CA. Primary open-angle glaucoma in African Americans. Int Ophthalmol Clin 2004;44(2):43–60. DOI: 10.1097/00004397-200404420-00006
  10. Gracitelli CPB, Zangwill LM, Diniz-Filho A, et al. Detection of glaucoma progression in individuals of African descent compared with those of European descent. JAMA Ophthalmol 2018;136(4):329–335. DOI: 10.1001/jamaophthalmol.2017.6836
  11. Akindipe TO, Aina OF, Onakoya Ao. Risk of depression and subjective quality of life among attendees of a West African glaucoma clinic. Int J Medecine Medical Sci 2011;1(2):432–435.
  12. Ayele FA, Zeraye B, Assefa Y, et al. The impact of glaucoma on quality of life in Ethiopia: a case-control study. BMC Ophthalmol 2017;17(1):248. DOI: 10.1186/s12886-017-0643-8
  13. Mbadugha CA, Onakoya AO, Aribaba OT, et al. A comparison of the NEIVFQ25 and GQL-15 questionnaires in Nigerian glaucoma patients. Clin Ophthalmol 2012;6:1411–1419. DOI: 10.2147/OPTH.S33592
  14. Odoulami L, Alamou S, Ngouffo H, et al. Quality of life of the patients followed-up for primary open angle glaucoma at the national teaching hospital of Cotonou-Benin Republic. Austin J Clin Ophthalmol 2018;5(2):1090.
  15. Onakoya AO, Mbadugha CA, Aribaba OT, et al. Quality of life of primary open angle glaucoma patients in lagos, Nigeria: clinical and sociodemographic correlates. J Glaucoma 2012;21(5):287–295. DOI: 10.1097/IJG.0b013e31820d7cfd
  16. Budenz DL, Barton K, Whiteside-de Vos J, et al. Prevalence of glaucoma in an urban West African population: the Tema Eye Survey. JAMA Ophthalmol 2013;131(5):651–658. DOI: 10.1001/jamaophthalmol.2013.1686
  17. WHO. Statistical Classification of Disease and Related Health Problems. Geneva: World Health organization; 2003. Geneva: WHO; 2003.
  18. Mangione CM, Lee PP, Gutierrez PR, et al. Development of the 25-item National Eye Institute Visual Function Questionnaire. Arch Ophthalmol 2001;119(7):1050–1058. DOI: 10.1001/archopht.119.7.1050
  19. Evans K, Law SK, Walt J, et al. The quality of life impact of peripheral versus central vision loss with a focus on glaucoma versus age-related macular degeneration. Clin Ophthalmol 2009;3:433–445. DOI: 10.2147/opth.s6024
  20. Kumar S, Ichhpujani P, Singh R, et al. The impact of primary open-angle glaucoma: quality of life in Indian patients. Indian J Ophthalmol 2018;66(3):416–419. DOI: 10.4103/ijo.IJO_847_17
  21. Chaturvedi R, Chaturvedi GD. Evaluation of quality of life due to visual impairment in patients with glaucoma. Int J Contemp Med 2016;3(4):1002–1004.
  22. Kumari N, Pandav SS, Gupta PC, et al. Quality of life and burden of care in glaucoma patients and their families in a South Asian population. J Clin Exp Ophthalmol 2017;8(4):1–6. DOI: 10.4172/2155-9570.1000669
  23. Kausar A, Ali M, Masud H, et al. Vision-related quality of life in Pakistani subjects with early or moderate glaucoma. Int Health 2018;10(6):517–523. DOI: 10.1093/inthealth/ihy052
  24. Picanco AAB, Picanco BC, Gusmao BM, et al. Quality of life among people with glaucoma: analysis according to the defect in the visual field. Rev Bras Oftalmol 2018;77(6):328–333. DOI: 10.5935/0034-7280.20180071
  25. van Gestel A, Webers CA, Beckers HJ, et al. The relationship between visual field loss in glaucoma and health-related quality-of-life. Eye (Lond) 2010;24(12):1759–1769. DOI: 10.1038/eye.2010.133
  26. Labiris G, Katsanos A, Fanariotis M, et al. Vision-specific quality of life in Greek glaucoma patients. J Glaucoma 2010;19(1):39–43. DOI: 10.1097/IJG.0b013e31819d5cf7
  27. Floriani I, Quaranta L, Rulli E, et al. Health-related quality of life in patients with primary open-angle glaucoma. An Italian multicentre observational study. Acta Ophthalmol 2016;94(5):e278–e286. DOI: 10.1111/aos.12890
  28. Sawada H, Fukuchi T, Abe H. Evaluation of the relationship between quality of vision and the visual function index in Japanese glaucoma patients. Graefes Arch Clin Exp Ophthalmol 2011;249(11):1721–1727. DOI: 10.1007/s00417-011-1779-5
  29. Wu N, Kong X, Gao J, et al. Vision-related quality of life in glaucoma patients and its correlations with psychological disturbances and visual function indices. J Glaucoma 2019;28(3):207–215. DOI: 10.1097/IJG.0000000000001178
  30. Alqudah A, Mansberger SL, Gardiner SK, et al. Vision-related quality of life in glaucoma suspect or early glaucoma patients. J Glaucoma 2016;25(8):629–633. DOI: 10.1097/IJG.0000000000000445
  31. Lin JC, Yang MC. Correlation of visual function with health-related quality of life in glaucoma patients. J Eval Clin Pract 2010;16(1): 134–140. DOI: 10.1111/j.1365-2753.2009.01135.x
  32. Sawada H, Yoshino T, Fukuchi T, et al. Assessment of the vision-specific quality of life using clustered visual field in glaucoma patients. J Glaucoma 2014;23(2):81–87. DOI: 10.1097/IJG.0b013e318265bbdc
  33. Wu P, Xi S, Xia H, et al. Survey on vision-related quality of life and self-management among patients with glaucoma. J Glaucoma 2014;23(2):75–80. DOI: 10.1097/IJG.0b013e318265bbf3
  34. Kuo YS, Liu CJ, Cheng HC, et al. Impact of socioeconomic status on vision-related quality of life in primary open-angle glaucoma. Eye (Lond) 2017;31(10):1480–1487. DOI: 10.1038/eye.2017.99
  35. Ringsdorf L, McGwin Jr G, Owsley C. Visual field defects and vision-specific health-related quality of life in African Americans and whites with glaucoma. J Glaucoma 2006;15(5):414–418. DOI: 10.1097/01.ijg.0000212252.72207.c2
  36. Machado LF, Kawamuro M, Portela RC, et al. Factors associated with vision-related quality of life in Brazilian patients with glaucoma. Arq Bras Oftalmol 2019;82(6):463–470. DOI: 10.5935/0004-2749.20190089
  37. Kumar S, Thakur S, Ichhpujani P. The impact of primary open-angle glaucoma: comparison of vision-specific (National Eye Institute Visual Function Questionnaire-25) and disease-specific (Glaucoma Quality of Life-15 and Viswanathan 10) patient-reported outcome (PRO) instruments. Indian J Ophthalmol 2019;67(1):83–88. DOI: 10.4103/ijo.IJO_798_18
  38. Labiris G, Giarmoukakis A, Larin R, et al. The clinical significance of glaucoma-related quality of life studies. Clin Exp Ophthalmol 2012;40(4):e235–236. DOI: 10.1111/j.1442-9071.2011.02655.x
  39. Suzukamo Y, Oshika T, Yuzawa M, et al. Psychometric properties of the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25), Japanese version. Health Qual Life Outcomes 2005;3:65. DOI: 10.1186/1477-7525-3-65
  40. Pardhan S, Gilchrist J, Douthwaite W, et al. Binocular inhibition: psychophysical and electrophysiological evidence. Optom Vis Sci 1990;67(9):688–691. DOI: 10.1097/00006324-199009000-00006
  41. Chun YS, Sung KR, Park CK, et al. Factors influencing vision-related quality of life according to glaucoma severity. Acta Ophthalmol 2019;97(2):e216–e224. DOI: 10.1111/aos.13918
  42. Sung KR, Chun YS, Park CK, et al. Vision-related quality of life in Korean glaucoma patients. J Glaucoma 2017;26(2):159–165. DOI: 10.1097/IJG.0000000000000575
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.