Citation Information :
Dubey S, Jain K, Mukhejee S. Iridocorneal Endothelial Syndrome with Coexisting Macular Edema and Neurosensory Detachment: An Unusual Case Report. J Curr Glaucoma Pract 2021; 15 (3):149-152.
The iridocorneal endothelial (ICE) syndrome is a sporadic, unilateral condition characterized by abnormalities of the cornea, anterior chamber angle, and iris affecting middle-aged women (3rd to 5th decade). It consists of three variants: progressive iris atrophy, Cogan–Reese syndrome—diffuse nevus or iris nodules, and Chandler syndrome—corneal endothelial abnormalities leading to corneal edema. This syndrome has an abnormal corneal endothelial cell layer (proliferative endotheliopathy), which migrates across the angle and onto the surface of the iris. It is a potentially blinding condition as a result of secondary glaucoma and/or corneal decompensation. Although few case reports have shown an association of ICE syndrome with macular edema; however, our case was unique in the sense that it was associated with neurosensory detachment (NSD). It can be suggested that PG analogs are not a good idea to be prescribed for secondary glaucoma management in patients with ICE syndrome as it can predispose to the development of macular edema with NSD.
Campbell DG, Shields MB, Smith TR. The corneal endothelium and the spectrum of essential iris atrophy. Am J Ophthalmol 1978;86(3):317–324. DOI: 10.1016/0002-9394(78)90232-5.
Wilson MC, Shields MB. A comparison of the clinical variations of the iridocorneal endothelial syndrome. Arch Ophthalmol 1989;107(10):1465–1468. DOI: 10.1001/archopht.1989.01070020539035.
Eagle RC, Font RL, Yanoff M, et al. Proliferative endotheliopathy with iris abnormalities. The iridocorneal endothelial syndrome. Arch Ophthalmol 1979;97(11):2104–2111. DOI: 10.1001/archopht.1979.01020020422002.
Aihara M. Glaucoma and iridocorneal endothelial (ICE) syndrome. Ophthalmology 2008;50:1420–1421.
Kocaoğlan H, Unlü N, Kanpolat A, et al. Macular edema and iridocorneal endothelial syndrome: a case report. Cornea 2005;24(2):221–223. DOI: 10.1097/01.ico.0000138840.37447.b9.
Fourmaux E, Velasque L. Progressive essential iris atrophy associated with chronic cystoid macular edema. J Fr Ophthalmol 2005;28(4):407–410. DOI: 10.1016/s0181-5512(05)81073-3.
Keita S, Tadashi M, Yui S, et al. Cystoid macular edema associated with iridocorneal endothelial syndrome: a case report. BMC Ophthalmol 2016;16(1):155. DOI: 10.1186/s12886-016-0333-y.
Artunay O, Senel A, Sengul A, et al. Central serous chorioretinopathy associated with topical latanoprost therapy. Ocul Immunol Inflamm 2011;19(6):453–455. DOI: 10.3109/09273948.2011.619680.
Ozdemir H, Karacorlu M, Karacorlu SA. Serous detachment of macula in cystoid macular edema associated with latanoprost. Eur J Ophthalmol 2008;18(6):1014–1016. DOI: 10.1177/112067210801800627.
Kalikivayi V, Joseph J, Mathews BT, et al. Reversal of retinal pigment epithelial detachment after cessation of topical travoprost therapy. Int Ophthalmol 2018;38(5):2227–2231. DOI: 10.1007/s10792-017- 0711-3.
