Journal of Current Glaucoma Practice

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VOLUME 15 , ISSUE 3 ( September-December, 2021 ) > List of Articles


Prevalence of Obstructive Sleep Apnea in Glaucoma Patients: A Systematic Review and Meta-analysis

Brian E Yu, Ronald Cheung, Cindy Hutnik, Monali S Malvankar-Mehta

Keywords : Glaucoma, Obstructive sleep apnea, Prevalence

Citation Information : Yu BE, Cheung R, Hutnik C, Malvankar-Mehta MS. Prevalence of Obstructive Sleep Apnea in Glaucoma Patients: A Systematic Review and Meta-analysis. J Curr Glaucoma Pract 2021; 15 (3):109-116.

DOI: 10.5005/jp-journals-10078-1301

License: CC BY-NC 4.0

Published Online: 27-01-2022

Copyright Statement:  Copyright © 2021; The Author(s).


Aim and objective: Obstructive sleep apnea (OSA) is a known systemic risk factor associated with glaucoma. The purpose of the study was to determine the overall prevalence of sleep apnea among patients with glaucoma. Design: A systematic review and meta-analysis. Participants: Not applicable. Materials and methods: A systematic literature search was performed through MEDLINE, EMBASE, and CINAHL and gray literature using Clinical, and ProQuest Dissertations and Theses and conferences held through the Association for Research in Vision and Ophthalmology, American Academy of Ophthalmology, and Canadian Society of Ophthalmology was done until June 10, 2020. Eligible articles were identified by reviewing the retrieved results. Data extracted included the total number of patients with glaucoma and the proportion of glaucoma patients with a co-occurring diagnosis of OSA. STATA 15.0 was used to perform the meta-analysis. Results: 544 articles were gathered from the databases and 40 records were collected via the gray literature search. Ten studies with 956 subjects were included for analysis. The results of the meta-analysis demonstrated a significant rate of OSA among glaucoma patients (ES = 0.17; CI: [0.08, 0.25]). Conclusion: We examine the prevalence of OSA in glaucoma patients and conclude that the prevalence of OSA in glaucoma patients is higher. Clinical significance: The findings in the ongoing investigation on the link between glaucoma and OSA continue to be unclear. The results from this study contribute to evidence of an association between the two diseases.

  1. Bendel RE, Kaplan J, Heckman M, et al. Prevalence of glaucoma in patients with obstructive sleep apnoea - a cross-sectional case-series. Eye 2008;22(9):1105–1109. DOI: 10.1038/sj.eye.6702846.
  2. Hong C, Trope G. Glaucoma. CMAJ 2015;187(12):E398–E399. DOI: 10.1503/cmaj.140401.
  3. Young T, Skatrud J, Peppard PE. CLINICIAN'S CORNER risk factors for obstructive sleep apnea. JAMA 2004;291(16):2013–2016. DOI: 10.1001/jama.291.16.2013.
  4. Nisha M, Saranyah K, Shankar M, et al. Enhanced saccharification of lignocellulosic agricultural biomass and increased bioethanol titre using acclimated Clostridium thermocellum DSM1313. 3 Biotech 2017;7(1):35. DOI: 10.1007/s13205-017-0606-z.
  5. Keenan TDL, Goldacre R, Goldacre MJ. Associations between obstructive sleep apnoea, primary open angle glaucoma and age-related macular degeneration: record linkage study. Br J Ophthalmol 2017;101(2):155–159. DOI: 10.1136/bjophthalmol-2015-308278.
  6. Cabrera M, Benavides AM, Hallaji NAE, et al. Risk of obstructive sleep apnea in open-angle glaucoma versus controls using the STOP-Bang questionnaire. Can J Ophthalmol 2018;53(1):76–80. DOI: 10.1016/j.jcjo.2017.07.008.
  7. Yuan-Yao F. Glaucoma progression in patients with obstructive sleep apnea-hypopnea syndrome: study of the CGMH polysomnography database. Investig Ophthalmol Vis Sci 2018;59(9):5110.
  8. Huon LK, Liu SYC, Camacho M, et al. The association between ophthalmologic diseases and obstructive sleep apnea: a systematic review and meta-analysis. Sleep Breath 2016;20(4):1145–1154. DOI: 10.1007/s11325-016-1358-4.
  9. Liu S, Lin Y, Liu X. Meta-analysis of association of obstructive sleep apnea with glaucoma. J Glaucoma 2016;25(1):1–7. DOI: 10.1097/IJG.0000000000000357.
  10. Chuang LH, Koh YY, Chen HSL, et al. Normal tension glaucoma in obstructive sleep apnea syndrome: a structural and functional study. Medicine (Baltimore) 2020;99(13):e19468. DOI: 10.1097/MD.0000000000019468.
  11. Mojon DS, Hess CW, Goldblum D, et al. Normal-tension glaucoma is associated with sleep apnea syndrome. Ophthalmologica 2002;216(3):180–184. DOI: 10.1159/000059625.
  12. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 2009;62(10):1006–1012. DOI: 10.1016/j.jclinepi.2009. 06.005.
  13. Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health 1998;52(6):377–384. DOI: 10.1136/jech. 52.6.377.
  14. Balbay EG, Balbay O, Annakkaya AN, et al. Obstructive sleep apnoea syndrome in patients with primary open-angle glaucoma. Hong Kong Med J 2014;20(5):379–385. DOI: 10.12809/hkmj134021.
  15. Ledina MJ, Ledina TM, Milanović VB, et al. Do glaucoma, nonarteritic ischemic anterior optic neuropathy and sleep apnea march hand in hand? Eur Respir J 2017;50:PA2324.
  16. Wozniak D, Bourne R, Peretz G, et al. Obstructive sleep apno ea in patients with primar y-open angle glaucoma: no role for a screening program. J Glaucoma 2019;28(8):668–675. DOI: 10.1097/IJG.0000000000001296.
  17. Khandgave TP, Puthran N, Ingole AB, et al. The assessment of sleep apnoea as a risk factor in glaucoma. J Clin Diagnostic Res 2013;7(7):1391–1393. DOI: 10.7860/JCDR/2013/5383.3147.
  18. Marcus DM, Costarides AP, Gokhale P, et al. Sleep disorders: a risk factor for normal-tension glaucoma? J Glaucoma 2001;10(3):177–183. DOI: 10.1097/00061198-200106000-00006.
  19. Mojon DS, Hess CW, Goldblum D, et al. Primary open-angle glaucoma is associated with sleep apnea syndrome. Ophthalmologica 2000;214(2):115–118. DOI: 10.1159/000027478.
  20. Shalaby AEO, Elshazly MI, El Sayed YM, et al. Co-existence of obstructive sleep apnea and primary open angle glaucoma. Egypt J Chest Dis Tuberc 2016;65(2):511–516. DOI: 10.1016/j.ejcdt.2015. 12.003.
  21. Wozniak D, Kean J, Peretz G, et al. Prevalence of obstructive sleep apnoea in glaucoma: the posag study. Investig Ophthalmol Vis Sci 2018;59(9):28–30.
  22. Roberts TV, Hodge C, Graham SL, et al. Prevalence of nocturnal oxygen desaturation and self-reported sleep-disordered breathing in glaucoma. J Glaucoma 2009;18(2):114–118. DOI: 10.1097/IJG.0b013e318179f80c.
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