Journal of Current Glaucoma Practice

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VOLUME 14 , ISSUE 1 ( January-April, 2020 ) > List of Articles

Original Article

Anterior Chamber Angle, Intraocular Pressure, and Globe Biometric Parameters in the Children with β-Thalassemia Major

Nermien SM El-Haddad

Keywords : Anterior chamber angle, Corneal curvature, Effective lens position, Globe biometric parameters and intraocular pressure, β-Thalassemia

Citation Information : El-Haddad NS. Anterior Chamber Angle, Intraocular Pressure, and Globe Biometric Parameters in the Children with β-Thalassemia Major. J Curr Glaucoma Pract 2020; 14 (1):30-36.

DOI: 10.5005/jp-journals-10078-1274

License: CC BY-NC 4.0

Published Online: 01-04-2019

Copyright Statement:  Copyright © 2020; The Author(s).


Background: To evaluate the intraocular pressure (IOP), anterior chamber angle (ACA), and globe biometric parameters in β-thalassemia major children and the correlations of these changes. Materials and methods: Eighty-four eyes were included (42 eyes of thalassemia patients and 42 eyes of control). All participates underwent head circumference and height measurements, full ophthalmic examination, anterior segment optical coherence tomography (AS-OCT), and A-scan biometry. Results: The temporal angle of anterior chamber (T-ACA) was significantly narrower in thalassemia patients with p value = 0.008. While the nasal angle showed a nonsignificant narrowing with p value = 0.153. This narrowing was positively correlated with the height, and negatively correlated with the head circumference. Intraocular pressure was statistically higher in thalassemia patients with p value = 0.000. The increased IOP was positively correlated with the head circumference and the lens thickness (LT) and negatively correlated with T-ACA, axial length (AL), vitreous chamber depth (VCD), and anterior chamber depth (ACD). Axial length, ACD, and VCD significantly decreased with p value = 0.000 for all with a positive correlation with the height and a negative correlation with the head circumference. The LT increased in thalassemia group with p value = 0.000. This increase was positively correlated with the head circumference and negatively with the height. Also, there was steeper corneal curvature in thalassemia group with p value = 0.023 and 0.015 (for K1 and K2, respectively). No significant change was observed in corneal thickness in both groups with p value = 0.810. Conclusion: Narrower T-ACA, increased IOP, shorter (AL, VCD, and ACD), steeper corneal curvature, and thicker lens were found in thalassemia patients.

  1. Taneja R, Malik P, Sharma M, et al. Multiple transfused thalassemia major: ocular manifestations in a hospital-based population. Indian J Ophthalmol 2010;58(2):125–130. DOI: 10.4103/0301-4738.60083.
  2. Aksoy A, Aslankurt M, Aslan L, et al. Ocular findings in children with thalassemia major in eastern mediterranean. Int J Ophthalmol 2014;7(1):118–121. DOI: 10.3980/j.issn.2222-3959.2014.01.22.
  3. Liaska A, Petrou P, Georgakopoulos C, et al. β-Thalassemia and ocular implications: a systematic review. BMC Ophthalmol 2016;16(3):102. DOI: 10.1186/s12886-016-0285-2.
  4. Gartaganis SP, Georgakopoulos CD, Exarchou A, et al. Alterations in conjunctival cytology and tear film dysfunction in patients with beta-thalassemia. Cornea 2003;22(2):591–597. DOI: 10.1097/00003226-200310000-00002.
  5. Sathwara N, Marwah K, Jethani J, et al. Ocular abnormalities in patients with beta-thalassemia on transfusion and chelation therapy. AIOC 2009;58(5):434–451.
  6. Chen HB, Kashiwagi K, Yamabayashi S, et al. Anterior chamber angle biometry: quadrant variation, age change and sex difference. Curr Eye Res 1998;17(2):120–124. DOI: 10.1076/ceyr.
  7. Nowroozzadeh MH, Kalantari Z, Namvar K, et al. Ocular refractive and biometric characteristics in patients with thalassaemia major. Clin Exp Optom 2011;94(4):361–366. DOI: 10.1111/j.1444-0938.2010.00579.x.
  8. Khalaj M, Sarokhani MR, Mahyar A, et al. Assessing refractive errors in beta-thalassemia major patients. J Guilan Uni Med Sci 2008;67:42–49.
  9. Heydarian S, Jafari R, Karami H. Refractive errors and ocular biometry components in thalassemia major patients. Int Ophthalmol 2016;36(3):267–271. DOI: 10.1007/s10792-015-0161-8.
  10. Elkitkat RS, El-Shazly A, Ebeid WM, et al. Relation of anthropometric measurements to ocular biometric changes and refractive error in children with thalassemia. Eur J Ophthalmol 2016. 5–10.
  11. Pereira GC, Allemann N. Ocular biometry, refractive error and correlation with height, age, gender and years of formal education. Arq Bras Oftalmol 2007;70(3):487–493. DOI: 10.1590/s0004-27492007000300017.
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