Journal of Current Glaucoma Practice

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VOLUME 11 , ISSUE 3 ( September-December, 2017 ) > List of Articles


Is Glaucoma a Neurodegeneration caused by Central Insulin Resistance: Diabetes Type 4?

Citation Information : Is Glaucoma a Neurodegeneration caused by Central Insulin Resistance: Diabetes Type 4?. J Curr Glaucoma Pract 2017; 11 (3):77-79.

DOI: 10.5005/jp-journals-10028-1228

License: CC BY 3.0

Published Online: 01-07-2015

Copyright Statement:  Copyright © 2017; The Author(s).


How to cite this article: Dada T. Is Glaucoma a Neurodegeneration caused by Central Insulin Resistance: Diabetes Type 4? J Curr Glaucoma Pract 2017;11(3):77-79.

  1. Glaucoma as a neurodegenerative disease. Curr Opin Ophthalmol 2007 Mar;18(2):110-114.
  2. What changes can we expect in the brain of glaucoma patients? Surv Ophthalmol 2007 Nov;52(Suppl 2):S122-S126.
  3. Glaucoma—Diabetes of the brain: a radical hypothesis about its nature and pathogenesis. Med Hypotheses 2014 May;82(5):535-546.
  4. Diabetes Type 4: a paradigm shift in the understanding of glaucoma, the brain specific diabetes and the candidature of insulin as a therapeutic agent. Curr Mol Med 2017 Apr;17(1):46-59.
  5. Alzheimer's disease is type 3 diabetes—evidence reviewed. J Diabetes Sci Technol 2008 Nov;2(6):1101-1113.
  6. Insulin promotes neuronal survival via the alternatively spliced protein kinase CδII isoform. J Biol Chem 2012 Mar;287(12):9299-9310.
  7. Insulin or bFGF and C2 ceramide increase newborn rat retinal ganglion cell survival rate. Biochem Biophys Res Commun 2003 Feb;301(2):564-571.
  8. Insulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes and Alzheimer's disease. Front Endocrinol (Lausanne) 2014 Oct;5:161.
  9. Insulin enhances nitric oxide production in trabecular meshwork cells via de novo pathway for tetrahydrobiopterin synthesis. Korean J Ophthalmol 2007 Mar;21(1):39-44.
  10. Nitrovasodilator effects on intraocular pressure and ocular facility in monkeys. Exp Eye Res 1994 Jan;58(1):99-105.
  11. Effect of the topical application of nitroglycerin on intraocular pressure in normal and glaucomatous monkeys. Exp Eye Res 1995 Mar;60(3):337-339.
  12. Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve. Invest Ophthalmol Vis Sci 2008 Nov;49(11):4903-4911.
  13. Mitochondrial dysfunction and insulin resistance: an update. Endocr Connect 2015 Mar;4(1):R1-R15.
  14. The OPA1 gene and optic neuropathy. Br J Ophthalmol 2003 Jan;87(1):2-3.
  15. Optic disc morphology of patients with OPA1 autosomal dominant optic atrophy. Br J Ophthalmol 2003 Jan;87(1):48-53.
  16. Insulin stimulated-glucose transporter Glut 4 is expressed in the retina. PlosOne 2012 Dec;7(12):e52959.
  17. Insulin antiapoptotic signaling involves insulin activation of the nuclear factor kappaB-dependent survival genes encoding tumor necrosis factor receptor-associated factor 2 and manganese-superoxide dismutase. J Biol Chem 1999 Oct;274(43):30596-30602.
  18. New insights into insulin: the anti-inflammatory effect and its clinical relevance. World J Diabetes 2014 Apr;5(2):89-96.
  19. Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans. Obesity (Silver Spring) 2015 Nov;23(11):2142-2148.
  20. Insulin blocks glutamate-induced neurotoxicity in differentiated SH-SY5Y neuronal cells. Behavioural Neurol 2014 May;2014:674164.
  21. NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species: implication for cell death. J Neurochem 1995 Nov;65(5):2016-2021.
  22. Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J Neurosci 1995 May;15(5 Pt 1):3318-3327.
  23. Tau accumulation, altered phosphorylation, and missorting promote neurodegeneration in glaucoma. J Neurosci 2016 May;36(21):5785-5798.
  24. Vitrreous fluid levels of beta-amyloid(1-42) and tau in patients with retinal diseases. Jpn J Ophthalmol 2005 Mar-Apr;49(2):106-108.
  25. The Alzheimer's A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc Natl Acad Sci U S A 2002;99(18):11830-11835.
  26. Expression and localization in the fish retina of a homologue of the Alzheimer's related PS1 gene. Neuroreport 1998 Sep;9(13):2049-2056.
  27. Immunoreactivity against tau, amyloid precursor protein, and beta-amyloid in the human retina. Invest Ophthalmol Visual Sci 1995 Jan;36(1):24-31.
  28. Early cytoskeletal protein modifications precede overt structural degeneration in the DBA/2J mouse model of glaucoma. Front Neurosci 2016 Nov;3(10):494.
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