Journal of Current Glaucoma Practice

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VOLUME 10 , ISSUE 1 ( January-April, 2016 ) > List of Articles

RESEARCH ARTICLE

Diurnal Curve of the Ocular Perfusion Pressure

Fabio N Kanadani, TCA Moreira, BSP Bezerra, MP Vianello, J Corradi, SK Dorairaj, TS Prata

Keywords : Diurnal curve, Glaucoma, Ocular perfusion pressure

Citation Information : Kanadani FN, Moreira T, Bezerra B, Vianello M, Corradi J, Dorairaj S, Prata T. Diurnal Curve of the Ocular Perfusion Pressure. J Curr Glaucoma Pract 2016; 10 (1):4-6.

DOI: 10.5005/jp-journals-10008-1195

License: CC BY-NC 4.0

Published Online: 00-04-2016

Copyright Statement:  Copyright © 2016; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Purpose: To describe the diurnal variation of the ocular perfusion pressure (OPP) in normal, suspects and glaucoma patients. Materials and methods: Seventy-nine subjects were enrolled in a prospective study. The diurnal curve of intraocular pressure (IOP) was performed and blood pressure measurements were obtained. Each participant was grouped into one of the following based upon the clinical evaluation of the optic disk, IOP and standard achromatic perimetry (SAP): 18 eyes were classified as normal (normal SAP, normal optic disk evaluation and IOP < 21 mm Hg in two different measurements), 30 eyes as glaucoma suspect (GS) (normal SAP and mean deviation (MD), C/D ration > 0.5 or asymmetry > 0.2 and/or ocular hypertension), 31 eyes as early glaucoma (MD < -6 dB, glaucomatous optic neuropathy and SAP and MDs on SAP. Standard achromatic perimetry was performed with the Octopus 3.1.1 Dynamic 24-2 program. Intraocular pressure and blood pressure measurements were taken at 6 am, 9 am, 12, 3 and 6 pm. The patients stayed in the seated position for 5 minutes prior to blood pressure measurements. Results: The mean IOP values in all groups did not follow any regular pattern. The peak IOP was found to be greater in suspect [18.70 ± 3.31 (mm Hg ± SD)] and glaucoma (18.77 ± 4.30 mm Hg) patients as compared to normal subjects (16.11 ± 2.27 mm Hg). In studying the diurnal variation of the OPP, we found lower values at 3 pm in normals (34.21 ± 2.07 mm Hg), at 9 am in suspects (54.35 ± 3.32 mm Hg) and at 12 pm in glaucoma patients (34.84 ± 1.44 mm Hg). Conclusion: Each group has a specific OPP variation during the day with the most homogeneous group being the suspect one. It is important to keep studying the IOP and OPP variation for increased comprehension of the pathophysiology of glaucomatous optic neuropathy.


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  1. Flammer J, Orgül S, Costa VP, Orzalesi N, Krieglstein GK, Serra LM, Renard JP, Stefánsson E. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res 2002;21(4):359-393.
  2. Aydin A, Wollstein G, Price LL, Schuman JS. Evaluating pulsatile ocular blood flow analysis in normal and treated glaucomatous eyes. Am J Ophthalmol 2003 Sep;136(3):448-453.
  3. Hayreh SS. Blood supply of the optic nerve head: a ‘reality check’. In: Pullunat LE, Harris A, Anderson DR, editors. Current Concepts on Ocular Blood Flow in Glaucoma. New York: Kugler; 1999. p. 3-31.
  4. Singleton CD, Robertson D, Byrne D, Joos KM. Effect of posture on blood and intraocular pressures in multiple system atrophy, pure autonomic failure, and baroreflex failure. Circulation 2003 Nov 11;108(19):2349-2354.
  5. Leske MC, Wu SY, Nemesure B, Hennis A. Incident openangle glaucoma and blood pressure. Arch Ophthalmol 2002 Jul;120(7):954-959.
  6. Hornova J. Normal intraocular pressure values in the Czech population. Cesk Slov Oftalmol 1997 May;53(2):88-93.
  7. Kitazawa Y, Horie T. Diurnal variation of intraocular pressure in primary open-angle glaucoma. Am J Ophthalmol 1975 Apr;79(4):557-566.
  8. Gherghel D, Orgül S, Dubler B, Lübeck P, Gugleta K, Flammer J. Is vascular regulation in the central retinal artery altered in persons with vasospasm? Arch Ophthalmol 1999 Oct;117(10):1359-1362.
  9. Gherghel D, Orgul S, Gugleta K, Gekkievea M, Flammer J. Relationship between ocular perfusion pressure and retrobulbar blood flow in pat ients with glaucoma with progressive damage. Am J Ophthalmol 2000 Nov;130(5): 597-605.
  10. Weigert G, Findl O, Luksch A, Rainer G, Kiss B, Vass C, Schmetterer L. Effects of moderate changes in intraocular pressure on ocular hemodynamics in patients with primary open-angle glaucoma and healthy controls. Ophthalmology 2005 Aug;112(8):1337-1342.
  11. Fuchsjäger-Mayrl G, Wally B, Georgopoulos M, Rainer G, Kircher K, Buehl W, Amoako-Mensah T, Eichler HG, Vass C, Schmetterer L. Ocular blood flow and systemic blood pressure in patients with primary open-angle glaucoma and ocular hypertension. Invest Ophthalmol Vis Sci 2004 Mar; 45(3):834-839.
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